2. Signaling Pathways
  3. Epigenetics
  4. DNA Methyltransferase
  5. DNMT1 Isoform

DNMT1

 

DNMT1 Related Products (17):

Cat. No. Product Name Effect Purity
  • HY-A0004
    Decitabine
    		Inhibitor 99.97%
    Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor.
  • HY-10586
    5-Azacytidine
    		Inhibitor 99.79%
    5-Azacytidine (Azacitidine; 5-AzaC; Ladakamycin) is a nucleoside analogue of cytidine that specifically inhibits DNA methylation.
  • HY-135146
    GSK-3484862
    		Inhibitor 99.62%
    GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1).
  • HY-13962
    SGI-1027
    		Inhibitor 99.35%
    SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC50s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.
  • HY-13642
    RG108
    		Inhibitor 99.85%
    RG108 (N-Phthalyl-L-tryptophan) is a non-nucleoside DNA methyltransferases (DNMTs) inhibitor (IC50=115 nM) that blocks the DNMTs active site.
  • HY-124326
    Laccaic acid A
    		Inhibitor
    Laccaic acid A is a orally active and DNA-competitive inhibitor of DNA methyltransferase 1 (Dnmt1) (Ki=310 nM; IC50=650 nM).
  • HY-101925
    CM-272
    		Inhibitor 99.27%
    CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities.
  • HY-B2230
    Hinokitiol
    		Inhibitor 98.97%
    Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases DNMT1 and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.
  • HY-13420
    Zebularine
    		Inhibitor 99.99%
    Zebularine (NSC309132; 4-Deoxyuridine) is a DNA methyltransferase inhibitor.
  • HY-15229
    Guadecitabine sodium
    		Inhibitor 98.05%
    Guadecitabine sodium (SGI-110 sodium) is a second-generation DNA methyltransferases (DNMT) inhibitor for research of acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS).
  • HY-B2194
    γ-Oryzanol
    		Inhibitor
    γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice.
  • HY-117421A
    CM-579 trihydrochloride
    		Inhibitor 98.03%
    CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively.
  • HY-12747
    DC_517
    		Inhibitor 99.41%
    DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 1.7 μM and 0.91 μM, respectively.
  • HY-12746
    DC-05
    		Inhibitor 99.08%
    DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC50 and a Kd of 10.3 μM and 1.09 μM, respectively.
  • HY-139664A
    (R)-GSK-3685032
    		Inhibitor 98.02%
    (R)-GSK-3685032 is the R-enantiomer of GSK-3685032.
  • HY-117421
    CM-579
    		Inhibitor
    CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively.
  • HY-19826
    Isofistularin-3
    		Inhibitor
    Isofistularin-3 is a direct, DNA-competitive DNMT1 inhibitor, with an IC50 of 13.5 μM.