1. Epigenetics
  2. Histone Methyltransferase
    DNA Methyltransferase
  3. CM-579

CM-579 

Cat. No.: HY-117421
Handling Instructions

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.

For research use only. We do not sell to patients.

CM-579 Chemical Structure

CM-579 Chemical Structure

CAS No. : 1846570-40-8

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100 mg USD 1500 Get quote

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Description

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].

IC50 & Target[1]

DNA Methyltransferase

32 nM (IC50)

DNMT1

1.5 nM (Kd)

DNMT3A

92 nM (IC50)

DNMT3B

1000 nM (IC50)

G9a

16 nM (IC50)

In Vitro

The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

492.65

Formula

C₂₉H₄₀N₄O₃

CAS No.

1846570-40-8

SMILES

CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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CM-579
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CM-579

Cat. No.: HY-117421