1. Epigenetics
  2. Histone Acetyltransferase
    DNA Methyltransferase

CM-579 hydrochloride 

Cat. No.: HY-117421A Purity: 94.69%
Handling Instructions

CM-579 hydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells.

For research use only. We do not sell to patients.

CM-579 hydrochloride Chemical Structure

CM-579 hydrochloride Chemical Structure

Size Price Stock
5 mg USD 250 Get quote
10 mg USD 390 Get quote
50 mg USD 1100 Get quote
100 mg USD 1500 Get quote

* Please select Quantity before adding items.

Other Forms of CM-579 hydrochloride:

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

CM-579 hydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].

IC50 & Target[1]

DNA Methyltransferase

32 nM (IC50)

DNMT1

1.5 nM (Kd)

DNMT3A

92 nM (IC50)

DNMT3B

1000 nM (IC50)

G9a

16 nM (IC50)

In Vitro

The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1].

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (236.25 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8900 mL 9.4498 mL 18.8997 mL
5 mM 0.3780 mL 1.8900 mL 3.7799 mL
10 mM 0.1890 mL 0.9450 mL 1.8900 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.93 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.93 mM); Clear solution

References
Molecular Weight

529.11

Formula

C₂₉H₄₁ClN₄O₃

SMILES

CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1.Cl

Storage

4°C, sealed storage, away from moisture

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
CM-579 hydrochloride
Cat. No.:
HY-117421A
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CM-579 hydrochloride

Cat. No.: HY-117421A