2448471-08-5
2448471-08-5
Chemical Structure
CM-579 trihydrochloride
- CAS No.: 2448471-08-5
- Formula:C29H43Cl3N4O3
- Molecular Weight:602.04
IUPAC Name: 6-methoxy-2-(5-methylfuran-2-yl)-N-((1-methylpiperidin-4-yl)methyl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine trihydrochloride
InChIKey: XKSDREMVFCQUPC-UHFFFAOYSA-N
SMILES: CN1CCC(CNC2=CC(C3=CC=C(C)O3)=NC4=CC(OCCCN5CCCC5)=C(OC)C=C24)CC1.Cl.Cl.Cl
Biological Activity: CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CM-579 trihydrochloride | 97.00% | CM-579 trihydrochloride is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.97
HY-117421CM-579 -
Similarity Score 0.86
HY-101925CM-272 -
Similarity Score 0.71
HY-175988DNMT/HDAC-IN-2 -
Similarity Score 0.65
HY-163803CM-444 -
Similarity Score 0.58
HY-176036MS1262 -
Similarity Score 0.58
HY-150510AMS8511 hydrochloride -
Similarity Score 0.57
HY-155020Antitumor agent-101 -
Similarity Score 0.57
HY-150510MS8511 -
Similarity Score 0.55
HY-161149CM-1758 -
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