MS8511 hydrochloride
Based on 1 Customer Validation
MS8511 (hydrochloride) is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC50 values of 100 nM (G9a) and 140 nM (GLP), and Kd values of 44 nM (G9a) and 46 nM (GLP). MS8511 (hydrochloride) reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 (hydrochloride) can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectal cancer, and other disease such as Alzheimer’s disease (AD), sickle cell disease, Prader−Willi syndrome (PWS).
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 3031788-28-7
- Formula: C28H42ClN5O3
- Molecular Weight:532.12
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Histone Methyltransferase Isoforms
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Biological Activity
Chemical Information
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CAS No. 3031788-28-7
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Appearance Solid
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Molecular Weight 532.12
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Formula C28H42ClN5O3
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Color Off-white to light yellow
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SMILES
COC1=CC(C(C=C1OCCCN2CCCC2)=NC(NC(C=C)=O)=C3)=C3NC4CCN(CC4)C(C)C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
Methanol : 30 mg/mL (56.38 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Methanol | 1 mM | 1.8793 mL | 9.3964 mL | 18.7928 mL | 46.9819 mL |
| 5 mM | 0.3759 mL | 1.8793 mL | 3.7586 mL | 9.3964 mL | |
| 10 mM | 0.1879 mL | 0.9396 mL | 1.8793 mL | 4.6982 mL | |
| 15 mM | 0.1253 mL | 0.6264 mL | 1.2529 mL | 3.1321 mL | |
| 20 mM | 0.0940 mL | 0.4698 mL | 0.9396 mL | 2.3491 mL | |
| 25 mM | 0.0752 mL | 0.3759 mL | 0.7517 mL | 1.8793 mL | |
| 30 mM | 0.0626 mL | 0.3132 mL | 0.6264 mL | 1.5661 mL | |
| 40 mM | 0.0470 mL | 0.2349 mL | 0.4698 mL | 1.1745 mL | |
| 50 mM | 0.0376 mL | 0.1879 mL | 0.3759 mL | 0.9396 mL |
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