2. Epigenetics
  3. DNA Methyltransferase
  4. (R)-GSK-3685032

(R)-GSK-3685032 

Cat. No.: HY-139664A Purity: 98.02% ee.: 99.329%
COA Handling Instructions

(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition.

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(R)-GSK-3685032 Chemical Structure

(R)-GSK-3685032 Chemical Structure

CAS No. : 2170140-50-6

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Based on 1 publication(s) in Google Scholar

Other Forms of (R)-GSK-3685032:

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Description

(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2].

IC50 & Target[1]

DNMT1

 

Molecular Weight

420.53

Appearance

Solid

Formula

C22H24N6OS
CAS No.
SMILES

N#CC1=C(N2CCC(CC2)N)N=C(C(C#N)=C1CC)S[[email protected]](C3=CC=CC=C3)C(N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvent & Solubility
In Vitro: 

DMSO : 60 mg/mL (142.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3780 mL 11.8898 mL 23.7795 mL
5 mM 0.4756 mL 2.3780 mL 4.7559 mL
10 mM 0.2378 mL 1.1890 mL 2.3780 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Keywords:

(R)-GSK-36850322170140-50-6DNA MethyltransferaseDNMTsDNA MTasesselectiveR-enantiomerDNA methyltransferasemethylated modificationcancerInhibitorinhibitorinhibit

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