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Isoforms Recommended:	DNMT1

Results for "

DNMT1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Cytotoxin (1) Apoptosis (5) Autophagy (2) Deubiquitinase (1) DNA Methyltransferase (14) E1/E2/E3 Enzyme (1) Histone Methyltransferase (4) Keap1-Nrf2 (1) Nucleoside Antimetabolite/Analog (1) Small Interfering RNA (siRNA) (3) Virus Protease (1)
By Research Areas:	Cancer (23) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (1) Metabolic Disease (2) Neurological Disease (1)

Inhibitors & Agonists

Natural
Products

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-A0084A

Procainamide 3 Publications Verification Procaine amide; SP 100	DNA Methyltransferase	Cardiovascular Disease Cancer
Procainamide is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1). Procainamide is a Class 1A antiarrhythmic agent. Procainamide has the potential for the research of cancer and arrhythmias ^[1] .

HY-123346

SW155246	DNA Methyltransferase	Cancer
SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC₅₀s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases ^[1].

HY-RS03908

DNMT1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
DNMT1 Human Pre-designed siRNA Set A contains three designed siRNAs for DNMT1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

DNMT1 Human Pre-designed siRNA Set A DNMT1 Human Pre-designed siRNA Set A

HY-RS03909

Dnmt1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dnmt1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Dnmt1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dnmt1 Mouse Pre-designed siRNA Set A Dnmt1 Mouse Pre-designed siRNA Set A

HY-RS03910

Dnmt1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Dnmt1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Dnmt1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Dnmt1 Rat Pre-designed siRNA Set A Dnmt1 Rat Pre-designed siRNA Set A

HY-135146

GSK-3484862 5+ Cited Publications	DNA Methyltransferase	Cancer
GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity ^[1] .

HY-15228

RX-3117 1 Publications Verification TV-1360; Fluorocyclopentenylcytosine	Nucleoside Antimetabolite/Analog Apoptosis	Cancer
RX-3117 (TV-1360) is a potent and orally active anticancer and antimetaboliteagent. RX-3117 inhibits DNA methyltransferase 1 (DNMT1). RX-3117 shows antiproliferative and anti-tumour activity. RX-3117 induces cell cycle arrest at S phase and apoptosis ^[1] .

HY-150249

GSK3735967	DNA Methyltransferase	Cancer
GSK3735967 is an selective, reversible, non-nucleoside inhibitor of *DNMT1* with an IC₅₀ value of 40 nM. GSK3735967 contains a planar dicyanopyridine core that can specifically embed DNMT1 bound hemimethylated CpG dinucleotides. GSK3735967 has three binding sites, one of which can bind to histone H4K20me3 ^[1] .

HY-103236

NSC232003 2 Publications Verification	E1/E2/E3 Enzyme	Cancer
NSC232003 is a highly potent and cell-permeable *UHRF1* inhibitor, which inhibits DNA methylation in vitro and disrupts DNMT1/UHRF1 interactions at a cellular level.

HY-12746

DC-05

1 Publications Verification

DNA Methyltransferase Cancer

DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 10.3 μM and 1.09 μM, respectively.
HY-12747

DC_517

2 Publications Verification

DNA Methyltransferase Cancer

DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 1.7 μM and 0.91 μM, respectively.

DC-05 1 Publications Verification	DNA Methyltransferase	Cancer
DC-05 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 10.3 μM and 1.09 μM, respectively.

DC_517 2 Publications Verification	DNA Methyltransferase	Cancer
DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 1.7 μM and 0.91 μM, respectively.

HY-135146A

(Rac)-GSK-3484862	Others	Cancer
(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity ^[1] .

HY-139664

GSK-3685032 3 Publications Verification	DNA Methyltransferase	Cancer
GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible *DNMT1*-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition ^[1].

HY-B2230

Hinokitiol 5 Publications Verification β-Thujaplicin	Keap1-Nrf2 DNA Methyltransferase Virus Protease	Infection Cancer
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases *DNMT1* and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

HY-13962

SGI-1027 5 Publications Verification	DNA Methyltransferase Apoptosis	Cancer
SGI-1027 is a DNA methyltransferase (DNMT) inhibitor, with IC₅₀s of 7.5 μM, 8 μM, and 12.5 μM for DNMT3B, DNMT3A, and DNMT1 with poly(dI-dC) as substrate.

HY-15647

BRD9539 1 Publications Verification	Histone Methyltransferase	Cancer
BRD9539 is a histone methyltransferase G9a inhibitor with an IC₅₀ of 6.3 μM. BRD9539 also inhibits PRC2 activity and is inactive against SUV39H1, NSD2 and DNMT1 ^[1].

HY-101925

CM-272 1 Publications Verification	Histone Methyltransferase DNA Methyltransferase Apoptosis	Cancer
CM-272 is a first-in-class, potent, selective, substrate-competitive and reversible dual G9a/DNA methyltransferases (DNMTs) inhibitor with antitumor activities. CM-272 inhibits G9a, *DNMT1, DNMT3A, DNMT3B* and GLP with IC₅₀s of 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively. CM-272 inhibits cell proliferation and promotes apoptosis, inducing IFN-stimulated genes and immunogenic cell death ^[1].

HY-139664A

(R)-GSK-3685032	DNA Methyltransferase	Cancer
(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible *DNMT1*-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition ^[1] .

HY-B2194

γ-Oryzanol 5+ Cited Publications	DNA Methyltransferase	Metabolic Disease Cancer
γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of *DNMT1* (IC₅₀=3.2 μM), *DNMT3a* (IC₅₀=22.3 μM).

HY-146887

USP7-IN-9	Deubiquitinase Apoptosis	Cancer
USP7-IN-9 is a highly potent ubiquitin-specific protease 7 (USP7) inhibitor with an IC₅₀ value of 40.8 nM. USP7-IN-9 can induce apoptosis and arrest cell progression at G0/G1 and S phases in RS4; 11 cells. USP7-IN-9 reduces the protein levels of oncoproteins MDM2 and DNMT1 and increases the protein levels of tumor suppressors p53 and p21 ^[1].

HY-19826

Isofistularin-3	DNA Methyltransferase ADC Cytotoxin Autophagy Apoptosis	Cancer
Isofistularin-3 is a direct, DNA-competitive *DNMT1* inhibitor, with an IC₅₀ of 13.5 μM. Isofistularin-3, as a DNA demethylating agent, induces cell cycle arrest and sensitization to TRAIL in cancer cells. Isofistularin-3 can be used as an ADC cytotoxin ^[1].

HY-139664B

(S)-GSK-3685032	Others	Cancer
(S)-GSK-3685032 is the isomer of GSK-3685032 (HY-139664), and can be used as an experimental control. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible *DNMT1*-selective inhibitor, with an IC₅₀ of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition ^[1].

HY-121093

DC-S239	Histone Methyltransferase	Cancer
DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC₅₀ value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity ^[1].

HY-111544

EML741	Histone Methyltransferase	Cancer
EML741 is a histone lysine methyltransferase G9a/GLP inhibitor, with an IC₅₀ of 23 nM, K_d of 1.13 μM for G9a. EML741 also inhibits DNMT1 (IC₅₀, 3.1 μM), with no effect on DNMT3a or DNMT3b. EML741 exhibits low cell toxicity, and is membrane permeable and blood-brain barrier penetrated ^[1].

HY-149389

PNMT-IN-1	Others	Endocrinology
PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a K_i value of 1.2 nM and a IC₅₀ value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC₅₀ value of 61 μM and 17 μM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor ^[1].

HY-139015

5-Aza-4'-thio-2'-deoxycytidine 5-Aza-T-dCyd; NTX-301	DNA Methyltransferase	Cancer
5-Aza-4'-thio-2'-deoxycytidine (5-Aza-T-dCyd) is an orally active DNA methyltransferase I (DNMT1) inhibitor. 5-Aza-4'-thio-2'-deoxycytidine, a sulfur-containing deoxy-cytidine analog, has the potential for DNA hypomethylating and has antitumor effects ^[1].

HY-17389

Genipin Maximum Cited Publications 11 Publications Verification (+)-Genipin	Autophagy	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

Hinokitiol 5 Publications Verification β-Thujaplicin	Infection Cupressaceae Classification of Application Fields Ketones, Aldehydes, Acids Source classification Plants Disease Research Fields Chamaecyparis obtusa	Keap1-Nrf2 DNA Methyltransferase Virus Protease
Hinokitiol is a component of essential oils isolated from Chymacyparis obtusa, reduces Nrf2 expression, and decreases *DNMT1* and UHRF1 mRNA and protein expression, with anti-infective, anti-oxidative, and anti-tumor activities.

γ-Oryzanol 5+ Cited Publications	Structural Classification Monophenols other families Classification of Application Fields Source classification Phenols Plants Disease Research Fields Steroids Cancer	DNA Methyltransferase
γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of *DNMT1* (IC₅₀=3.2 μM), *DNMT3a* (IC₅₀=22.3 μM).

Genipin Maximum Cited Publications 11 Publications Verification (+)-Genipin	Structural Classification Neurological Disease Classification of Application Fields Source classification Metabolic Disease Plants Endogenous metabolite Human Gut Microbiota Metabolites Iridoids Terpenoids Rubiaceae Gardenia jasminoides Ellis Inflammation/Immunology Disease Research Fields	Autophagy
Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research ^[1] .

DNMT1 Antibody (YA781)	WB, IHC-P, FC	Human
DNMT1 Antibody (YA781) is a non-conjugated and Mouse origined monoclonal antibody about 183 kDa, targeting to DNMT1. It can be used for WB,IHC-P,FC assays with tag free, in the background of Human.

Dnmt1 Antibody (YA476)	WB, ICC/IF, IHC-P	Human, Mouse
Dnmt1 Antibody (YA476) is a non-conjugated and Rabbit origined monoclonal antibody about 183 kDa, targeting to Dnmt1. It can be used for WB,ICC/IF,IHC-P assays with tag free, in the background of Human, Mouse.

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