1. Epigenetics
  2. Histone Methyltransferase
  3. DC-S239

DC-S239 

Cat. No.: HY-121093 Purity: 99.43%
Handling Instructions

DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC50 value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity.

For research use only. We do not sell to patients.

DC-S239 Chemical Structure

DC-S239 Chemical Structure

CAS No. : 303141-21-1

Size Price Stock Quantity
5 mg USD 240 In-stock
Estimated Time of Arrival: December 31
10 mg USD 384 In-stock
Estimated Time of Arrival: December 31
25 mg USD 760 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1160 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

DC-S239 is a selective histone methyltransferase SET7 inhibitor with an IC50 value of 4.59 μM. DC-S239 also displays selectivity for DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a. DC-S239 has anticancer activity[1].

IC50 & Target

IC50: 4.59 μM (SET7)[1]

In Vitro

DC-S239 inhibits DNMT1, DOT1L, EZH2, NSD1, SETD8 and G9a by less than 45%, while it inhibits SET7 by 90% at concentrations of 100 μM[1].
DC-S239 (0-100 μM, 120 h) can inhibit the proliferation of MCF7, HL60 and MV4-11 cells in a dose-dependent manner but no significant effect on the activity of HCT116 and DHL4 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: MCF7, HL60, DHL4, MV4-11 and HCT116 cell lines
Concentration: 0-100 μM
Incubation Time: 120 h
Result: Inhibited MCF7 and HL60 with the IC50 values of 10.93 μM and 16.43 μM, respectively.
Molecular Weight

349.36

Formula

C15H15N3O5S

CAS No.
SMILES

O=C(OCC)C1=C(SC(C(NC2=CC=CC([N+]([O-])=O)=C2)=O)=C1C)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (357.80 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8624 mL 14.3119 mL 28.6238 mL
5 mM 0.5725 mL 2.8624 mL 5.7248 mL
10 mM 0.2862 mL 1.4312 mL 2.8624 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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DC-S239
Cat. No.:
HY-121093
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