2. Epigenetics
  3. DNA Methyltransferase
  4. SW155246

SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases.

For research use only. We do not sell to patients.

SW155246 Chemical Structure

SW155246 Chemical Structure

CAS No. : 420092-79-1

Size Price Stock Quantity
1 mg USD 30 In-stock
5 mg USD 90 In-stock
10 mg USD 144 In-stock
25 mg USD 288 In-stock
50 mg USD 460 In-stock
100 mg USD 737 In-stock
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Based on 1 publication(s) in Google Scholar

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DNA Methyltransferase DNMT1 DNMT3 MGMT

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Description

SW155246 is a DNA methyltransferase (DNMT1) selective inhibitor with IC50s of 1.2 and 38 μM for hDNMT1 and mDNMT3A, respectively. SW155246 can be used for the research of cancer and other diseases[1].

Molecular Weight

378.79

Formula

C16H11ClN2O5S
CAS No.
Appearance

Solid

Color

Light brown to brown

SMILES

ClC1=CC=C(C=C1[N+]([O-])=O)S(NC2=CC=C(C3=C2C=CC=C3)O)(=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (660.00 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6400 mL 13.1999 mL 26.3999 mL
5 mM 0.5280 mL 2.6400 mL 5.2800 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6400 mL 13.1999 mL 26.3999 mL 65.9996 mL
5 mM 0.5280 mL 2.6400 mL 5.2800 mL 13.1999 mL
10 mM 0.2640 mL 1.3200 mL 2.6400 mL 6.6000 mL
15 mM 0.1760 mL 0.8800 mL 1.7600 mL 4.4000 mL
20 mM 0.1320 mL 0.6600 mL 1.3200 mL 3.3000 mL
25 mM 0.1056 mL 0.5280 mL 1.0560 mL 2.6400 mL
30 mM 0.0880 mL 0.4400 mL 0.8800 mL 2.2000 mL
40 mM 0.0660 mL 0.3300 mL 0.6600 mL 1.6500 mL
50 mM 0.0528 mL 0.2640 mL 0.5280 mL 1.3200 mL
60 mM 0.0440 mL 0.2200 mL 0.4400 mL 1.1000 mL
80 mM 0.0330 mL 0.1650 mL 0.3300 mL 0.8250 mL
100 mM 0.0264 mL 0.1320 mL 0.2640 mL 0.6600 mL
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SW155246 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SW155246420092-79-1SW 155246SW-155246DNA MethyltransferaseDNMTsDNA MTasesDNA methyltransferaseDNMT1 inhibitorhDNMT1mDNMT3AcancerInhibitorinhibitorinhibit

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