1. Epigenetics
  2. Histone Methyltransferase
  3. BRD9539

BRD9539 

Cat. No.: HY-15647 Purity: 99.78%
Handling Instructions

BRD9539 inhibits G9a activity with an IC50 of 6.3 μM, inhibits PRC2 activity with a similar IC50.

For research use only. We do not sell to patients.

BRD9539 Chemical Structure

BRD9539 Chemical Structure

CAS No. : 1374601-41-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
25 mg USD 312 In-stock
Estimated Time of Arrival: December 31
50 mg USD 552 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

    BRD9539 purchased from MCE. Usage Cited in: Theranostics. 2018 Apr 15;8(10):2884-2895.

    Plk1 levels are decreased companied with p53K373me2 decline in HCT116 cells treated with BRD9539.
    • Biological Activity

    • Technical Information

    • Purity & Documentation

    • References

    Description

    BRD9539 inhibits G9a activity with an IC50 of 6.3 μM, inhibits PRC2 activity with a similar IC50. target: G9a, PRC2; IC50: 6.3 μM ( G9a ), 6.3 uM ( PRC2 ); BRD9539 is a more potent biochemical inhibitor than its methyl-ester analogue BRD4770, with 20% remaining G9a activity compared to 45% of BRD4770 at screening concentration.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : ≥ 35 mg/mL (87.62 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.5035 mL 12.5175 mL 25.0350 mL
    5 mM 0.5007 mL 2.5035 mL 5.0070 mL
    10 mM 0.2504 mL 1.2518 mL 2.5035 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    Molecular Weight

    399.44

    Formula

    C₂₄H₂₁N₃O₃

    CAS No.

    1374601-41-8

    SMILES

    O=C(C1=CC=C2C(N=C(NC(C3=CC=CC=C3)=O)N2CCCC4=CC=CC=C4)=C1)O

    Shipping

    Room temperature in continental US; may vary elsewhere

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
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    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

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    Inquiry Information

    Product Name:
    BRD9539
    Cat. No.:
    HY-15647
    Quantity:

    BRD9539

    Cat. No.: HY-15647