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  4. (Rac)-GSK-3484862

(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity.

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(Rac)-GSK-3484862 Chemical Structure

(Rac)-GSK-3484862 Chemical Structure

CAS No. : 2170136-02-2

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Based on 1 publication(s) in Google Scholar

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Description

(Rac)-GSK-3484862 is the isomer of GSK-3484862 (HY-135146), and can be used as an experimental control. GSK-3484862 is a non-covalent inhibitor for DNA methyltransferase (Dnmt1). GSK-3484862 induces DNA hypomethylation to against cancer. GSK-3484862 mediates dramatic demethylation in murine embryonic stem cells with minimal non-specific toxicity[1][2].

Molecular Weight

365.45

Formula

C19H19N5OS
CAS No.
Appearance

Solid

Color

Brown to orange

SMILES

O=C(N)C(SC1=NC(N(C)C)=C(C#N)C(CC)=C1C#N)C2=CC=CC=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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(Rac)-GSK-3484862 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-GSK-34848622170136-02-2OthersDNAmethyltransferase1Dnmt1hypomethylationepigenetictherapies5-AzacytidineInhibitorinhibitorinhibit

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