1. Epigenetics
    Anti-infection
  2. DNA Methyltransferase
    Parasite
  3. Nanaomycin A

Nanaomycin A 

Cat. No.: HY-103397
Handling Instructions

Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM.

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Nanaomycin A Chemical Structure

Nanaomycin A Chemical Structure

CAS No. : 52934-83-5

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Description

Nanaomycin A is the first selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells[1]. Nanaomycin A inhibits in vitro growth of the human malaria parasite Plasmodium falciparum with an IC80 value of 33.1 nM[2].

IC50 & Target[1]

DNMT3B

500 nM (IC50)

In Vitro

Nanaomycin A (10-10000 nM; 72 hours) has a distinct cytotoxic effect in all three cell lines[1].
Nanaomycin A (0.5, 5 μM; 72 hours) reveals induction of RASSF1A protein expression in A549 cells[1].
Nanaomycin A (5 μM; 72 hours) has an 18-fold relative induction[1].
Nanaomycin A not affects the enzymatic activity of DNMT1[1].

Cell Cytotoxicity Assay[1]

Cell Line: HCT116 (colon), A549 (lung), and HL60 (bone marrow) human tumor cell lines
Concentration: 10, 100, 1000, 10000 nM
Incubation Time: 72 hours
Result: Had a distinct cytotoxic effect in all three cell lines.

Western Blot Analysis[1]

Cell Line: A549 cells
Concentration: 0.5, 5 μM
Incubation Time: 72 hours
Result: Revealed induction of RASSF1A protein expression.

RT-PCR[1]

Cell Line: A549 cells
Concentration: 5 μM
Incubation Time: 72 hours
Result: Had an 18-fold relative induction.
Molecular Weight

302.28

Formula

C₁₆H₁₄O₆

CAS No.

52934-83-5

SMILES

O=C(O)C[[email protected]]1CC(C(C2=C3C(O)=CC=C2)=O)=C(C3=O)[[email protected]](C)O1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Nanaomycin ADNA MethyltransferaseParasiteDNMTsDNA MTasesDNMT3BantibioticssilencedtumorsuppressorgenesmalariaparasitePlasmodiumfalciparumInhibitorinhibitorinhibit

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Nanaomycin A
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