52934-83-5
52934-83-5
Chemical Structure
Nanaomycin A
- CAS No.: 52934-83-5
- Formula:C16H14O6
- Molecular Weight:302.28
IUPAC Name: 2-((1S,3R)-9-hydroxy-1-methyl-5,10-dioxo-3,4,5,10-tetrahydro-1H-benzo[g]isochromen-3-yl)acetic acid
InChIKey: ZCJHPTKRISJQTN-JGVFFNPUSA-N
SMILES: O=C(O)C[C@H]1CC(C(C2=C3C(O)=CC=C2)=O)=C(C3=O)[C@H](C)O1
Biological Activity: Nanaomycin A is a selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A inhibits the in vitro growth of human Plasmodium falciparum with an IC80 of 33.1 nM[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Nanaomycin A | 98.13% | Nanaomycin A is a selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A inhibits the in vitro growth of human Plasmodium falciparum with an IC80 of 33.1 nM. | ||||||||||||||||||||
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Nanaomycin A (Standard) | ≥98% | Nanaomycin A (Standard) is the analytical standard of Nanaomycin A (HY-103397). This product is intended for research and analytical applications. Nanaomycin A is a selective DNMT3B inhibitor with an IC50 of 500 nM. Nanaomycin A inhibits the in vitro growth of human Plasmodium falciparum with an IC80 of 33.1 nM. | ||||||||||||||||||||
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References
- [1]. Kuck D, et al.Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells.Mol Cancer Ther. 2010 Nov;9(11):3015-23. [Content Brief]
- [2]. Tanaka Y, et al.Heme-dependent radical generation: possible involvement in antimalarial action of non-peroxide microbial metabolites, nanaomycin A and radicicol.J Antibiot (Tokyo). 1999 Oct;52(10):880-8. [Content Brief]
