8-Desmethyleleutherin
8-Desmethyleleutherin (Compound 2) is an antibacterial agent that can be extracted from the bulbs of Eleutherine americana. 8-Desmethyleleutherin has MIC values of both 62.5 µg/mL for S. aureus strains ATCC27664 and ATCC25923.
For research use only. We do not sell to patients.
- CAS No.: 808148-30-3
- Formula: C15H14O4
- Molecular Weight:258.27
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MDA-MB-231 | EC50 |
0.475 μM
Compound: 35
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Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase after 5 days
Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase after 5 days
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[PMID: 24436995] |
| MDA-MB-231 | EC50 |
1.361 μM
Compound: 35
|
Cytotoxicity against human MDA-MB-231 cells overexpressing DT-diaphorase after 5 days
Cytotoxicity against human MDA-MB-231 cells overexpressing DT-diaphorase after 5 days
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[PMID: 24436995] |
| MDA-MB-231 | EC50 |
2.095 μM
Compound: 35
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Cytotoxicity against wild-type human MDA-MB-231 cells after 5 days
Cytotoxicity against wild-type human MDA-MB-231 cells after 5 days
|
[PMID: 24436995] |
| MDA-MB-231 | EC50 |
359.15 μM
Compound: 35
|
Cytotoxicity against wild-type human MDA-MB-231 cells treated for 4 hrs under anoxic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition
Cytotoxicity against wild-type human MDA-MB-231 cells treated for 4 hrs under anoxic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition
|
[PMID: 24436995] |
| MDA-MB-231 | EC50 |
4.1 μM
Compound: 35
|
Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase treated for 4 hrs under aerobic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition
Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase treated for 4 hrs under aerobic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition
|
[PMID: 24436995] |
| MDA-MB-231 | EC50 |
41.85 μM
Compound: 35
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Cytotoxicity against wild-type human MDA-MB-231 cells treated for 4 hrs under aerobic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition
Cytotoxicity against wild-type human MDA-MB-231 cells treated for 4 hrs under aerobic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition
|
[PMID: 24436995] |
| MDA-MB-231 | EC50 |
86.5 μM
Compound: 35
|
Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase treated for 4 hrs under anoxic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition
Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase treated for 4 hrs under anoxic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition
|
[PMID: 24436995] |
Chemical Information
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CAS No. 808148-30-3
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Molecular Weight 258.27
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Formula C15H14O4
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SMILES
O=C1C2=C([C@H](O[C@H](C2)C)C)C(C3=C(O)C=CC=C31)=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
8-Desmethyleleutherin Related Classifications
HY-N16339 Related Classifications
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