2256079-52-2
2256079-52-2
Chemical Structure
CM-444
- CAS No.: 2256079-52-2
- Formula:C27H30N6O5
- Molecular Weight:518.56
InChIKey: DDJFEVNAMKGVES-UHFFFAOYSA-N
SMILES: O=C(C1=CN=C(N2CCC(CNC3=CC(C4=CC=C(C)O4)=NC5=CC(OC)=C(OC)C=C35)CC2)N=C1)NO
Biological Activity: CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models[1].
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CM-444 | CM-444 is inhibitor for HDAC (IC50 is 6 nM-0.6 μM) and DNA methyltransferases (DNMT, IC50 is 1.8-2.3 μM). CM-444 is an inducer for the differentiation of acute myeloid leukemia cells. CM-444 exhibits anti-leukemic activity and improves the survival rate in mouse models. | |||||||||||||||||||||
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References
Keywords
