PIM-1/HDAC-IN-1
PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor, with an IC50 of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC50 values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase.
For research use only. We do not sell to patients.
- CAS No.: 2897622-19-2
- Formula: C22H19N3O3
- Molecular Weight:373.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 62.39 ± 3. nM (IC50) |
HDAC1 63.65 ± 3. nM (IC50) |
HDAC 65.94 ± 3. nM (IC50) |
HDAC2 132.62 nM (IC50) |
HDAC4 265.47 nM (IC50) |
HDAC3 323.02 nM (IC50) |
HDAC8 406.66 nM (IC50) |
PIM1 343.87 ± 1 nM (IC50) |
Chemical Information
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CAS No. 2897622-19-2
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Molecular Weight 373.40
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Formula C22H19N3O3
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SMILES
N#CC1=C(C=C(N=C1OCCCC(NO)=O)C2=CC=CC=C2)C3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PIM-1/HDAC-IN-1 Related Classifications
HY-143233 Related Classifications
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