HDAC6-IN-66
HDAC6-IN-66 is a potent and selective histone deacetylase (HDAC) 6 inhibitor with an IC50 of 1.8 nM. HDAC6-IN-66 induces α-tubulin acetylation over histone H3. HDAC6-IN-66 can be used for the research of cancer.
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- CAS No.: 3095060-23-1
- Formule: C19H15N3O3
- Masse moléculaire:333.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
HDAC6 1.8 nM (IC50) |
HDAC3 73.6 nM (IC50) |
HDAC1 104.9 nM (IC50) |
In Vitro
HDAC6-IN-66 (Compound 5j) selectively inhibits HDAC6 (IC50 = 1.8 nM), with significantly higher IC50 against other HDAC isoforms (HDAC1 : 104.9 nM, HDAC3 : 73.6 nM; HDAC4 : 271.3 nM)[1].
HDAC6-IN-66 exhibits significant antiproliferative activity against HCT116 cells (GI50 = 3.1 μM), and shows mild inhibitory activity against other cancer cell lines such as MDA-MB-231 (GI50 = 22.3 μM) and HCC827 cells (GI50 = 15.9 μM)[1].
HDAC6-IN-66 (0.5-10 μM, 24 h) induces acetylation of α-tubulin in HCT116 and MDA-MB-231 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3095060-23-1
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Masse moléculaire 333.34
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Formule C19H15N3O3
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SMILES
O=C(NO)C1=CC=C(CN2N=C(C3=CC=CO3)C4=C2C=CC=C4)C=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-66 Related Classifications
HY-178333 Related Classifications
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