Cat. No.: HY-149669

PH14

Customer Review

Based on 1 Customer Validation

PH14 is a dual PI3K/HDAC inhibitor with IC₅₀ values of 20.3 nM and 24.5 nM for PI3Kα and HDAC3, respectively. PH14 has antiproliferative activity and also induces apoptosis in Jeko-1 cells. PH14 can be used in cancer research, such as lymphoma.

For research use only. We do not sell to patients.

Purity: 99.29%
CAS No.: 3053430-96-6
Formula: C₃₄H₃₉N₉O₅
Molecular Weight:653.73

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

PH14 Chemical Structure

CAS No.: 3053430-96-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

PI3Kα

20.3 nM (IC₅₀)

HDAC3

24.5 nM (IC₅₀)

All PI3K Isoforms :

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HL-60	IC₅₀	0.9 μM Compound: PH14	Antiproliferative activity against human HL-60 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Antiproliferative activity against human HL-60 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]
JeKo-1	IC₅₀	0.5 μM Compound: PH14	Antiproliferative activity against human JeKo-1 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Antiproliferative activity against human JeKo-1 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]
L02	IC₅₀	>100 μM Compound: PH14	Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Cytotoxicity against human HL7702 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]
MDA-MB-231	IC₅₀	1.5 μM Compound: PH14	Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Antiproliferative activity against human MDA-MB-231 cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]
MM1.S	IC₅₀	2.9 μM Compound: PH14	Antiproliferative activity against human MM1.S cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis Antiproliferative activity against human MM1.S cells incubated for 48 hrs by resazurin dye based fluorescence micro plate reader analysis	[PMID: 37948955]

Chemical Information

CAS No. 3053430-96-6
Appearance Solid
Molecular Weight 653.73
Formula C₃₄H₃₉N₉O₅
Color White to pink
SMILES

COC1=NC(N2CCOCC2)=NC(C3=CC=C(NC(NC4=CC=C(C(NCCCCCC(NC5=CC=CC=C5N)=O)=O)C=C4)=O)C=C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (76.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.5297 mL

7.6484 mL

15.2968 mL

5 mM

0.3059 mL

1.5297 mL

3.0594 mL

10 mM

0.1530 mL

0.7648 mL

1.5297 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Deng J, et al. Discovery of benzamide-based PI3K/HDAC dual inhibitors with marked pro-apoptosis activity in lymphoma cells. Eur J Med Chem. 2023 Nov 3;262:115915. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.5297 mL	7.6484 mL	15.2968 mL	38.2421 mL
	5 mM	0.3059 mL	1.5297 mL	3.0594 mL	7.6484 mL
	10 mM	0.1530 mL	0.7648 mL	1.5297 mL	3.8242 mL
	15 mM	0.1020 mL	0.5099 mL	1.0198 mL	2.5495 mL
	20 mM	0.0765 mL	0.3824 mL	0.7648 mL	1.9121 mL
	25 mM	0.0612 mL	0.3059 mL	0.6119 mL	1.5297 mL
	30 mM	0.0510 mL	0.2549 mL	0.5099 mL	1.2747 mL
	40 mM	0.0382 mL	0.1912 mL	0.3824 mL	0.9561 mL
	50 mM	0.0306 mL	0.1530 mL	0.3059 mL	0.7648 mL
	60 mM	0.0255 mL	0.1275 mL	0.2549 mL	0.6374 mL

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PH14

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Bioactive Compound Library Max

All PI3K Isoforms

All HDAC Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

PH14 Related Classifications

HY-149669 Related Classifications