SAHA-OH
SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis.
For research use only. We do not sell to patients.
- CAS No.: 2857098-30-5
- Formula: C15H22N2O4
- Molecular Weight:294.35
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
HDAC6 23 nM (IC50) |
HDAC1 237 nM (IC50) |
HDAC3 359 nM (IC50) |
HDAC2 399 nM (IC50) |
HDAC8 1070 nM (IC50) |
SAHA-OH (0.67-10.76 μM; 51 h) shows inhibition in bone marrow macrophages[1].
SAHA-OH (0.01 μM; 3 h) treatment in BMMØs (bone marrow macrophages) reduces IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2) and GROα (CXCL1) secretions[1].
SAHA-OH (10 μM; 4 or 9 h) treatment induces acetylation of cytoplasmic α-tubulin and nuclear histone H3[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates macrophage apoptosis[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates B cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:BMMØs (bone marrow macrophages)
-
Concentration:0.67-10.76 μM
-
Incubation Time:51 h
-
Result:Showed IC50 value in unstimulated BMMØs of 1.26 μM, and showed IC50 value in LPS-stimulated BMMØs of 10.76 μM.
-
Cell Line:BMMØs (bone marrow macrophages)
-
Concentration:0-30 μM
-
Incubation Time:3 h
-
Result:Resulted in a 24- to 26-fold increase in cellular viability as compared to the SAHA treatment.
-
Cell Line:B cells
-
Concentration:0-30 μM
-
Incubation Time:3 h
-
Result:Resulted in a 5-fold enhancement in viability and a 3-fold decrease in cell death for the B cell population.
-
Cell Line:BMMØs (bone marrow macrophages)
-
Concentration:10 μM
-
Incubation Time:4 or 9 h
-
Result:Resulted in the acetylation of α-tubulin.
Induced the acetylation of histone H3 compared to no treatment (NT).
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:LPS-induced endotoxemia mouse model[1]
-
Dosage:50 mg/kg
-
Administration:Intraperitoneal injection; 50 mg/kg; once
-
Result:Reduced proinflammatory cytokine secretions by about 50% compared to no treatment (NT) control mice.
Showed similar architecture as no treatment (NT) control and displayed well-organized lymphoid follicles.
Chemical Information
-
CAS No. 2857098-30-5
-
Molecular Weight 294.35
-
Formula C15H22N2O4
-
SMILES
O=C(NO)CCCCCCC(NC1=CC=C(CO)C=C1)=O
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SAHA-OH Related Classifications
HY-151569 Related Classifications
Powered by Bioz