2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. HDAC Apoptosis
  4. SAHA-OH

SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis.

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SAHA-OH Chemical Structure

SAHA-OH Chemical Structure

CAS No. : 2857098-30-5

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SAHA-OH Related Antibodies

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Description

SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis[1].

IC50 & Target[1]

HDAC6

23 nM (IC50)

HDAC1

237 nM (IC50)

HDAC3

359 nM (IC50)

HDAC2

399 nM (IC50)

HDAC8

1070 nM (IC50)

In Vitro

SAHA-OH (0.67-10.76 μM; 51 h) shows inhibition in bone marrow macrophages[1].
SAHA-OH (0.01 μM; 3 h) treatment in BMMØs (bone marrow macrophages) reduces IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2) and GROα (CXCL1) secretions[1].
SAHA-OH (10 μM; 4 or 9 h) treatment induces acetylation of cytoplasmic α-tubulin and nuclear histone H3[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates macrophage apoptosis[1].
SAHA-OH (0-30 μM; 3 h) treatment attenuates B cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SAHA-OH Related Antibodies

Cell Viability Assay[1]

Cell Line: BMMØs (bone marrow macrophages)
Concentration: 0.67-10.76 μM
Incubation Time: 51 h
Result: Showed IC50 value in unstimulated BMMØs of 1.26 μM, and showed IC50 value in LPS-stimulated BMMØs of 10.76 μM.

Apoptosis Analysis[1]

Cell Line: BMMØs (bone marrow macrophages)
Concentration: 0-30 μM
Incubation Time: 3 h
Result: Resulted in a 24- to 26-fold increase in cellular viability as compared to the SAHA treatment.

Cell Cytotoxicity Assay[1]

Cell Line: B cells
Concentration: 0-30 μM
Incubation Time: 3 h
Result: Resulted in a 5-fold enhancement in viability and a 3-fold decrease in cell death for the B cell population.

Western Blot Analysis[1]

Cell Line: BMMØs (bone marrow macrophages)
Concentration: 10 μM
Incubation Time: 4 or 9 h
Result: Resulted in the acetylation of α-tubulin.
Induced the acetylation of histone H3 compared to no treatment (NT).
In Vivo

SAHA-OH (intraperitoneal injection; 50 mg/kg; once) treatment prevents splenic organ damage, and reduces plasma proinflammatory cytokine levels in LPS-induced endotoxemia mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced endotoxemia mouse model[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; 50 mg/kg; once
Result: Reduced proinflammatory cytokine secretions by about 50% compared to no treatment (NT) control mice.
Showed similar architecture as no treatment (NT) control and displayed well-organized lymphoid follicles.
Molecular Weight

294.35

Formula

C15H22N2O4
CAS No.
SMILES

O=C(NO)CCCCCCC(NC1=CC=C(CO)C=C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SAHA-OH Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAHA-OH2857098-30-5HDACApoptosisHistone deacetylasesanti-inflammatory activityBMM?sbone marrow macrophagesB cellInhibitorinhibitorinhibit

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