2857098-30-5
2857098-30-5
Chemical Structure
SAHA-OH
- CAS No.: 2857098-30-5
- Formula:C15H22N2O4
- Molecular Weight:294.35
IUPAC Name: N1-hydroxy-N8-(4-(hydroxymethyl)phenyl)octanediamide
InChIKey: ASNHHXCJSXFUNP-UHFFFAOYSA-N
SMILES: O=C(NO)CCCCCCC(NC1=CC=C(CO)C=C1)=O
Biological Activity: SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis[1].
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SAHA-OH | SAHA-OH is a selective HDAC6 inhibitor (IC50=23 nM), shows a 10- to 47-fold selectivity for HDAC6 compared to HDAC 1, 2, 3, and 8. SAHA-OH shows anti-inflammatory activity, and attenuates macrophage apoptosis. | |||||||||||||||||||||
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References
Keywords
