2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. TNG260

TNG260 is a CoREST-selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 leads to HDAC1 inhibition, reverses anti-PD1 resistance driven by loss of STK11. TNG260 decreases intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing.

For research use only. We do not sell to patients.

TNG260 Chemical Structure

TNG260 Chemical Structure

CAS No. : 2935964-98-8

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Based on 1 publication(s) in Google Scholar

Other Forms of TNG260:

TNG260 Related Antibodies

Top Publications Citing Use of Products

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

TNG260 is a CoREST-selective deacetylase (CoreDAC) inhibitor. TNG260 inhibits HDAC1 with 10-fold selectivity over HDAC3. TNG260 leads to HDAC1 inhibition, reverses anti-PD1 resistance driven by loss of STK11. TNG260 decreases intratumoral infiltration of neutrophils. TNG260 exhibits immune-mediated cell killing[1].

IC50 & Target[1]

HDAC1

 

HDAC3

 

Clinical Trial
Molecular Weight

383.44

Formula

C20H18FN3O2S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

NC1=CC=C(C2=CC=C(F)C=C2)C=C1NC(C3=CC=C([S@](=O)(C)=N)C=C3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 99.91%

COA (254 KB) HNMR (280 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
References
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TNG260 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TNG2602935964-98-8TNG 260TNG-260HDACHistone deacetylasesInhibitorinhibitorinhibit

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