NMDAR/HDAC-IN-1
NMDAR/HDAC-IN-1 (Compound 9d) is a dual NMDAR and HDAC inhibitor with a Ki of 0.59 μM for NMDAR and IC50 values of 2.67, 8.00, 2.21, 0.18 and 0.62 μM for HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8, respectively. NMDAR/HDAC-IN-1 efficiently penetrates the blood brain barrier.
For research use only. We do not sell to patients.
- Formula: C22H28N2O3
- Molecular Weight:368.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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NMDA Receptor 0.59 μM (Ki) |
HDAC6 0.18 μM (IC50) |
HDAC8 0.62 μM (IC50) |
HDAC3 2.21 μM (IC50) |
HDAC1 2.67 μM (IC50) |
HDAC2 8.00 μM (IC50) |
NMDAR/HDAC-IN-1 (Compound 9d) increases the level of AcTubulin in MV4-11 cells and rescues PC-12 cells from H2O2-induced cytotoxicity with EC50 of 0.94 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 368.47
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Formula C22H28N2O3
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SMILES
CC12CC3CC(C1)(CC(C3)(C2)NC(/C=C/C4=CC=C(C=C4)C(NO)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NMDAR/HDAC-IN-1 Related Classifications
HY-147873 Related Classifications
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