NMDAR/HDAC-IN-1
NMDAR/HDAC-IN-1 (Compound 9d) is a dual NMDAR and HDAC inhibitor with a Ki of 0.59 μM for NMDAR and IC50 values of 2.67, 8.00, 2.21, 0.18 and 0.62 μM for HDAC1, HDAC2, HDAC3, HDAC6 and HDAC8, respectively. NMDAR/HDAC-IN-1 efficiently penetrates the blood brain barrier.
For research use only. We do not sell to patients.
- Formula: C22H28N2O3
- Molecular Weight:368.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
All iGluR Isoforms
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Biological Activity
Description
IC50 & Target
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NMDA Receptor 0.59 μM (Ki) |
HDAC6 0.18 μM (IC50) |
HDAC8 0.62 μM (IC50) |
HDAC3 2.21 μM (IC50) |
HDAC1 2.67 μM (IC50) |
HDAC2 8.00 μM (IC50) |
In Vitro
NMDAR/HDAC-IN-1 (Compound 9d) increases the level of AcTubulin in MV4-11 cells and rescues PC-12 cells from H2O2-induced cytotoxicity with EC50 of 0.94 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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Molecular Weight 368.47
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Formula C22H28N2O3
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SMILES
CC12CC3CC(C1)(CC(C3)(C2)NC(/C=C/C4=CC=C(C=C4)C(NO)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)