JPS035
JPS035 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS035 degrades class I histone deacetylase (HDAC). JPS035 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells.
(Pink: HDAC1 and HDAC2 ligand (HY-50934); Blue: VHL ligand (HY-136164); Black: linker (HY-W105741)).
For research use only. We do not sell to patients.
- CAS No.: 2669785-84-4
- Formula: C49H65N7O7S
- Molecular Weight:896.15
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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HDAC1 |
HDAC2 |
VHL |
Chemical Information
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CAS No. 2669785-84-4
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Molecular Weight 896.15
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Formula C49H65N7O7S
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SMILES
CC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=C(C=C(C3=C(C)N=CS3)C=C2)OCCCCCCCCCCCC(NC4=CC=C(C=C4)C(NC5=C(C=CC=C5)N)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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