1. Cell Cycle/DNA Damage
    Epigenetics
    PROTAC
  2. HDAC
    PROTACs
  3. JPS035

JPS035 

Cat. No.: HY-145818
Handling Instructions

JPS035 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS035 degrades class I histone deacetylase (HDAC). JPS035 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells.

For research use only. We do not sell to patients.

JPS035 Chemical Structure

JPS035 Chemical Structure

CAS No. : 2669785-84-4

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Description

JPS035 is a benzamide-based Von Hippel-Lindau (VHL) E3-ligase proteolysis targeting chimeras (PROTAC). JPS035 degrades class I histone deacetylase (HDAC). JPS035 is potent HDAC1/2 degrader correlated with greater total differentially expressed genes and enhanced apoptosis in HCT116 cells[1].

Molecular Weight

896.15

Formula

C49H65N7O7S

CAS No.
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JPS035
Cat. No.:
HY-145818
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