2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. HDAC-IN-38

HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5).

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HDAC-IN-38 Chemical Structure

HDAC-IN-38 Chemical Structure

CAS No. : 2408123-36-2

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HDAC-IN-38 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE HDAC-IN-38

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5)[1].

IC50 & Target

HDAC8

0.533 μM (IC50)

HDAC6

1.27 μM (IC50)

HDAC3

2.86 μM (IC50)

HDAC1

3.82 μM (IC50)

HDAC5

6.27 μM (IC50)

HDAC2

6.62 μM (IC50)

Molecular Weight

461.98

Formula

C27H28ClN3O2
CAS No.
SMILES

O=C(NO)/C=C/C1=CC=C(C=C1)CNCCCN2C3=C(CCC4=C2C=C(C=C4)Cl)C=CC=C3
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC-IN-38 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC-IN-382408123-36-2HDACHistone deacetylasesSH-SY5Y cellsVascular cognitive impairmentNeurodegenerative diseaseHistone deacetylase inhibitorshippocampal atrophyInhibitorinhibitorinhibit

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