1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. HDAC-IN-38

HDAC-IN-38 

Cat. No.: HY-146351
Handling Instructions

HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5).

For research use only. We do not sell to patients.

HDAC-IN-38 Chemical Structure

HDAC-IN-38 Chemical Structure

CAS No. : 2408123-36-2

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Description

HDAC-IN-38 (compound 13) is a potent HDAC inhibitor. HDAC-IN-38 shows similar micro-molar inhibitory activity toward HDAC1, 2, 3, 5, 6, and 8. HDAC-IN-38 increases cerebral blood flow (CBF), attenuates cognitive impairment, and improves hippocampal atrophy. HDAC-IN-38 also increases the level of histone acetylation (H3K14 or H4K5)[1].

IC50 & Target

HDAC8

0.533 μM (IC50)

HDAC6

1.27 μM (IC50)

HDAC3

2.86 μM (IC50)

HDAC1

3.82 μM (IC50)

HDAC5

6.27 μM (IC50)

HDAC2

6.62 μM (IC50)

Molecular Weight

461.98

Formula

C27H28ClN3O2

CAS No.
SMILES

O=C(NO)/C=C/C1=CC=C(C=C1)CNCCCN2C3=C(CCC4=C2C=C(C=C4)Cl)C=CC=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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HDAC-IN-38
Cat. No.:
HY-146351
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