HDAC-IN-88
Based on 1 publication(s) in Google Scholar
HDAC-IN-88 (Compound HJ-9) is the inhibitor for HDAC that inhibits HDAC6, HDAC1, HDAC2, HDAC8 and HDAC3 with IC50s of 0.226, 1.103, 2.308, 3.255 and 3.864 μM, respectively. HDAC-IN-88 inhibits the proliferation of cancer cell HepG2, HCT116 and MV4-11 with IC50 of 5.47, 9.78 and 0.38 μM, inhibits the migration of HCT116, arrests the cell cycle at G0/G1 phase, and induces apoptosis and autophagy in MV4-11. HDAC-IN-88 reduces ROS level and mitochondrial membrane potential. HDAC-IN-88 exhibits antimalarial activity that inhibits P. falciparum 3D7 with EC50 of 165 nM. HDAC-IN-88 also exhibits anti-angiogenic activity.
For research use only. We do not sell to patients.
- Formula: C23H36N4O4
- Molecular Weight:432.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) HDAC-IN-88
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Biological Activity
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HDAC6 0.226 μM (IC50) |
HDAC1 1.103 μM (IC50) |
HDAC2 2.308 μM (IC50) |
HDAC8 3.255 μM (IC50) |
HDAC3 3.864 μM (IC50) |
Chemical Information
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Molecular Weight 432.56
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Formula C23H36N4O4
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SMILES
O=C(NO)CCCCC1=CN(N=N1)[C@@H]2C([H])[C@]3([H])CC[C@@H](C)[C@@]4([H])[C@]35[C@](C[C@](C)(OO5)CC4)([H])C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC-IN-88 Related Classifications
HY-168962 Related Classifications
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