HDAC6-IN-85
Based on 1 Customer Validation
HDAC6-IN-85 is a selective HDAC6 inhibitor, with pIC50 values of 5.4, 5.5, 5.9, and 4.8 against rHDAC1, rHDAC3, rHDAC6, and rHDAC8, respectively. HDAC6-IN-85 can be used in the research of cervical cancer, lung cancer, and colon cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.58%
- CAS 番号: 948837-73-8
- 分子式: C12H14O2S3
- 分子量:286.43
-
保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
-
溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
HDAC1 5.4 (pIC50) |
HDAC3 5.5 (pIC50) |
HDAC6 5.9 (pIC50) |
HDAC8 4.8 (pIC50) |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
4.56 μM
Compound: 3a
|
Inhibition of recombinant HDAC1 expressed in HEK293 cells
Inhibition of recombinant HDAC1 expressed in HEK293 cells
|
[PMID: 18558669] |
| HEK293 | IC50 |
1.22 μM
Compound: 3a
|
Inhibition of recombinant HDAC6 expressed in HEK293 cells
Inhibition of recombinant HDAC6 expressed in HEK293 cells
|
[PMID: 18558669] |
| HeLa | IC50 |
0.375 μM
Compound: 3a
|
Inhibition of nuclear HDAC isolated from human HeLa cells
Inhibition of nuclear HDAC isolated from human HeLa cells
|
[PMID: 18558669] |
| HeLa | IC50 |
4.67 μM
Compound: 3a
|
Inhibition of HDAC in human HeLa cells
Inhibition of HDAC in human HeLa cells
|
[PMID: 18558669] |
| HeLa | IC50 |
1.96 μM
Compound: 3a
|
Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay
Cytotoxicity against human HeLa cells after 72 hrs by alamar blue assay
|
[PMID: 18558669] |
体外実験
HDAC6-IN-85 (Compound 7) potently inhibits the HDAC isozyme mixture in HeLa nuclear extracts, with a pIC50 of 6.3[1].
HDAC6-IN-85 inhibits the proliferation of HeLa cervical cancer cells with a pIC50 value of 5.6[1].
HDAC6-IN-85 inhibits recombinant HDAC isozymes, with the highest inhibitory potency against rHDAC6 (pIC50 = 5.9) and the lowest inhibitory potency against rHDAC8 (pIC50 = 4.8)[1].
HDAC6-IN-85 inhibits the proliferation of A549 lung cancer cells and RKO colon cancer cells, with a pIC50 value of 5.2 for the former and 5.7 for the latter[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
-
CAS 番号 948837-73-8
-
性状 Solid
-
分子量 286.43
-
分子式 C12H14O2S3
-
Color Light yellow to yellow
-
SMILES
O=C(CSC(SCC)=S)C1=CC=C(C=C1)OC
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (349.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
-
データシート (269 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4913 mL | 17.4563 mL | 34.9125 mL | 87.2814 mL |
| 5 mM | 0.6983 mL | 3.4913 mL | 6.9825 mL | 17.4563 mL | |
| 10 mM | 0.3491 mL | 1.7456 mL | 3.4913 mL | 8.7281 mL | |
| 15 mM | 0.2328 mL | 1.1638 mL | 2.3275 mL | 5.8188 mL | |
| 20 mM | 0.1746 mL | 0.8728 mL | 1.7456 mL | 4.3641 mL | |
| 25 mM | 0.1397 mL | 0.6983 mL | 1.3965 mL | 3.4913 mL | |
| 30 mM | 0.1164 mL | 0.5819 mL | 1.1638 mL | 2.9094 mL | |
| 40 mM | 0.0873 mL | 0.4364 mL | 0.8728 mL | 2.1820 mL | |
| 50 mM | 0.0698 mL | 0.3491 mL | 0.6983 mL | 1.7456 mL | |
| 60 mM | 0.0582 mL | 0.2909 mL | 0.5819 mL | 1.4547 mL | |
| 80 mM | 0.0436 mL | 0.2182 mL | 0.4364 mL | 1.0910 mL | |
| 100 mM | 0.0349 mL | 0.1746 mL | 0.3491 mL | 0.8728 mL |
HDAC6-IN-85 関連分類
HY-184525 関連分類
Powered by Bioz