PD-L1/HDAC-IN-1
PD-L1/HDAC-IN-1 (Compound 14) is the inhibitor for PD-L1 and HDAC that inhibits PD-1/PD-L1 interaction, HDAC2 and HDAC3 with IC50 of 88.10, 27.98 and 14.47 nM, respectively. PD-L1/HDAC-IN-1 exhibits slight cytotoxicity in MCF-7 (IC50=19.34 μM). PD-L1/HDAC-IN-1 upregulates the expression of PD-L1 and CXCL10, promoting anti-tumour immune response by recruiting T-cell infiltration into TME.
For research use only. We do not sell to patients.
- CAS No.: 2923313-69-1
- Formula: C42H46ClN3O7
- Molecular Weight:740.28
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC3 14.47 nM (IC50) |
HDAC2 27.98 nM (IC50) |
PD-1/PD-L1 88.10 nM (IC50) |
Chemical Information
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CAS No. 2923313-69-1
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Molecular Weight 740.28
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Formula C42H46ClN3O7
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SMILES
N#CC1=CC=CC(COC(C=C(C(Cl)=C2)OCC3=C(C(C4=CC(OCCCCCCC(NO)=O)=CC=C4)=CC=C3)C)=C2CN5[C@H](CCCC5)C(O)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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