NRIP1 - nuclear receptor interacting protein 1 Gene

Also Known as CAKUT3; RIP140

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8204

About NRIP1

Cytogenetic location: 21q11.2-q21.1 Genomic coordinates (GRCh38): 21:14,961,235-15,065,936 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in fat (RPKM 19.2), endometrium (RPKM 12.9) and 25 other tissues.

Summary

Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the Estrogen receptor. [provided by RefSeq, Jul 2008]

NRIP1 Products (1)

mRNA Protein Name
NM_003489.4 NP_003480.2 nuclear receptor-interacting protein 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
21628546 GOA
enables nuclear estrogen receptor binding IPI
IPI: Inferred from physical interaction
7641693 GOA
enables nuclear glucocorticoid receptor binding IPI
IPI: Inferred from physical interaction
10364267 GOA
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
11518808 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
1266503 GOA
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
7641693 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
10364267 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to estradiol stimulus IDA
IDA: Inferred from direct assay
15831516 GOA
involved in circadian regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21628546 GOA
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
21628546 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
10364267 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
7641693 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
15831516 GOA
located in nucleus IDA
IDA: Inferred from direct assay
7641693 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor-interacting protein 1

  • nuclear factor RIP140

NRIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NRIP1 P48552 RARA Homo sapiens P10276-2
Y2H Prey Pooling
25416956
Intra
NRIP1 P48552 GPRASP3 Homo sapiens Q6PI77
Y2H Array
32296183
Intra
NRIP1 P48552 GPRASP3 Homo sapiens Q6PI77
Y2H Prey Pooling
32296183
Intra
NRIP1 P48552 GPRASP3 Homo sapiens Q6PI77
Validated Y2H
32296183
Intra
NRIP1 P48552 ESRRG Homo sapiens P62508-3
Validated Y2H
32296183
Intra
NRIP1 P48552 PKNOX2 Homo sapiens Q96KN3
Y2H Prey Pooling
32296183
Intra
NRIP1 P48552 PKNOX2 Homo sapiens Q96KN3
Validated Y2H
32296183
Intra
NRIP1 P48552 PKNOX2 Homo sapiens Q96KN3
Y2H Array
32296183
Intra
NRIP1 P48552 ZNF366 Homo sapiens Q8N895
Pull Down
17085477
Intra
NRIP1 P48552 ARPC3 Homo sapiens O15145
Y2H Array
25416956
Intra
NRIP1 P48552 ARPC3 Homo sapiens O15145
Y2H Prey Pooling
25416956
Intra
NRIP1 P48552 RARA Homo sapiens P10276
Y2H Prey Pooling
25416956
Intra
NRIP1 P48552 RARA Homo sapiens P10276
Y2H Array
25416956
Intra
NRIP1 P48552 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
NRIP1 P48552 GOLGA2 Homo sapiens Q08379
Validated Y2H
32296183
Intra
NRIP1 P48552 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
NRIP1 P48552 DNMT1 Homo sapiens P26358
Pull Down
17972916
Intra
NRIP1 P48552 DNMT1 Homo sapiens P26358
Anti Bait CoIP
17972916
Intra
NRIP1 P48552 CEP70 Homo sapiens Q8NHQ1
Y2H Pooling
16189514
Intra
NRIP1 P48552 CEP70 Homo sapiens Q8NHQ1
Y2H Fragment Pooling
35914814
Intra
NRIP1 P48552 LDOC1 Homo sapiens O95751
Y2H Array
19060904
Intra
NRIP1 P48552 LDOC1 Homo sapiens O95751
Y2H Pooling
16189514
Intra
NRIP1 P48552 LDOC1 Homo sapiens O95751
Y2H Pooling
19060904
Intra
NRIP1 P48552 PRMT1 Homo sapiens Q99873
Anti Bait CoIP
17053781
Intra
NRIP1 P48552 PRMT1 Homo sapiens Q99873
Anti Tag CoIP
17053781
Intra
NRIP1 P48552 CTBP1 Homo sapiens Q13363
Pull Down
17085477
Intra
NRIP1 P48552 FHL1 Homo sapiens Q13642
Pull Down
19401155
Intra
NRIP1 P48552 FHL1 Homo sapiens Q13642
Anti Tag CoIP
19401155
Cross: Cross-species interaction Intra: Intraspecies interaction

NRIP1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P89767 RIP140 Antibody (YA9111) WB, IP human

Related Diseases

Diseases Alias
Congenital Anomalies Of Kidney And Urinary Tract 3

  • CAKUT3
Cakut

  • Renal Or Urinary Tract Malformation

  • Congenital Anomalies Of Kidney And Urinary Tract

  • Congenital Anomaly Of Kidney And Urinary Tract

  • Congenital Anomalies Of The Kidney And Urinary Tract

  • Kidney And Urinary Tract, Anomalies, Congenital

  • Renal Hypodysplasia, Nonsyndromic, 1
Posterior Urethral Valves

  • Posterior Urethral Valve

  • Congenital Posterior Urethral Valves

  • Puv
Embryonal Carcinoma

  • Embryonal Neoplasm

  • Embryonal Cancer

  • Primary Extragonadal Embryonal Carcinoma

  • Embryo Neoplasm

  • Carcinoma Embryonal

  • Cancer Embryonal

  • Carcinoma, Embryonal

  • Extragonadal Embryonal Carcinoma

  • Cancer, Embryonal
Infertility
Down Syndrome

  • Trisomy 21

  • Complete Trisomy 21 Syndrome

  • Down'S Syndrome

  • Trisomy 21 Syndrome

  • Down'S Syndrome - Trisomy 21

  • Downs Syndrome

  • G Trisomy

  • 47,Xx,+21

  • 47,Xy,+21

  • Trisomy G

  • Down Syndrome, Susceptibility To

  • Chromosome 21 Trisomy

  • Trisomy 21 Nos

  • Abnormal Autosomes 21
Chronic Kidney Disease

  • Chronic Renal Disease

  • Chronic Kidney Failure

  • Ckd

  • Chronic Renal Failure

  • Kidney Failure, Chronic

  • Chronic Renal Failure Syndrome

  • Crf

  • Renal Failure - Chronic

  • Renal Failure Chronic

  • Chronic Kidney Diseases

  • Chronic Kidney Disease Stage 5

  • Ckd - [Chronic Kidney Disease]

  • Crf - [Chronic Renal Failure]

  • Chronic Kidney Impairment

  • Chronic Renal Impairment

  • Chronic Kidney Shutdown

  • Chronic Hypoxic Kidney Failure

  • Chronic Kidney Collapse

  • Chronic Renal Insufficiency

  • Chronic Kidney Toxaemia

  • Chronic Kidney Hypofunction

  • Chronic Renal Suppression

  • Chronic Renal Failure, Stage 5

  • Ckd - [Chronic Kidney Disease] Stage 5

  • End Stage Kidney Failure

  • End Stage Renal Failure

  • End Stage Kidney Disease

  • End Stage Renal Disease

  • End Stage Chronic Renal Failure

  • Esrf - [End Stage Renal Failure]

  • Esrd - [End Stage Renal Diseases]

  • Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09571 NRIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22690 Nrip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NRIP1 VGNC VGNC:43969
Bos taurus NRIP1 VGNC VGNC:32263
Mus musculus NRIP1 MGD MGI:1315213
Rattus norvegicus NRIP1 RGD RGD:1311850
Felis catus NRIP1 VGNC VGNC:68567
Macaca mulatta NRIP1 VGNC VGNC:75529
Others NRIP1 NCBI