ZNF366 - zinc finger protein 366 Gene

Also Known as DCSCRIPT; DC-SCRIPT

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 167465

Summary

Enables nuclear Estrogen Receptor binding activity and transcription corepressor activity. Involved in negative regulation of intracellular Estrogen Receptor signaling pathway; negative regulation of transcription by RNA polymerase II; and response to estrogen. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Broad expression in placenta (RPKM 4.6), fat (RPKM 4.5) and 21 other tissues.

ZNF366 Products (1)

mRNA Protein Name
NM_152625.3 NP_689838.1 zinc finger protein 366

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables nuclear estrogen receptor binding IDA
IDA: Inferred from direct assay
17085477 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17085477 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
17085477 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of intracellular estrogen receptor signaling pathway IDA
IDA: Inferred from direct assay
17085477 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
17085477 GOA
involved in response to estrogen IDA
IDA: Inferred from direct assay
17085477 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
17085477 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF366 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF366 Q8N895 DNM2 Homo sapiens P50570-2
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 DNM2 Homo sapiens P50570-2
Validated Y2H
32814053
Intra
ZNF366 Q8N895 DNM2 Homo sapiens P50570-2
Y2H Array
32814053
Intra
ZNF366 Q8N895 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
ZNF366 Q8N895 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
ZNF366 Q8N895 DMWD Homo sapiens G5E9A7
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 DMWD Homo sapiens G5E9A7
Validated Y2H
32814053
Intra
ZNF366 Q8N895 DMWD Homo sapiens G5E9A7
Y2H Array
32814053
Intra
ZNF366 Q8N895 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
Intra
ZNF366 Q8N895 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
Intra
ZNF366 Q8N895 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
ZNF366 Q8N895 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
ZNF366 Q8N895 PINK1 Homo sapiens Q9BXM7
Validated Y2H
32814053
Intra
ZNF366 Q8N895 PINK1 Homo sapiens Q9BXM7
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 PINK1 Homo sapiens Q9BXM7
Y2H Array
32814053
Intra
ZNF366 Q8N895 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
ZNF366 Q8N895 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
ZNF366 Q8N895 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
ZNF366 Q8N895 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra
ZNF366 Q8N895 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra
ZNF366 Q8N895 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra
ZNF366 Q8N895 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
ZNF366 Q8N895 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
ZNF366 Q8N895 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra
ZNF366 Q8N895 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra
ZNF366 Q8N895 A2M Homo sapiens P01023
Validated Y2H
32814053
Intra
ZNF366 Q8N895 A2M Homo sapiens P01023
Y2H Array
32814053
Intra
ZNF366 Q8N895 A2M Homo sapiens P01023
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
ZNF366 Q8N895 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
ZNF366 Q8N895 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra
ZNF366 Q8N895 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra
ZNF366 Q8N895 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
25416956
Intra
ZNF366 Q8N895 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra
ZNF366 Q8N895 NRIP1 Homo sapiens P48552
Pull Down
17085477
Intra
ZNF366 Q8N895 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
ZNF366 Q8N895 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Intra
ZNF366 Q8N895 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
ZNF366 Q8N895 ESR1 Homo sapiens P03372
Pull Down
17085477
Intra
ZNF366 Q8N895 ESR1 Homo sapiens P03372
Anti Bait CoIP
17085477
Intra
ZNF366 Q8N895 ESR1 Homo sapiens P03372
Anti Tag CoIP
17085477
Intra
ZNF366 Q8N895 CTBP1 Homo sapiens Q13363
Anti Bait CoIP
17085477
Intra
ZNF366 Q8N895 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra
ZNF366 Q8N895 PEX1 Homo sapiens O43933
Y2H Array
32814053
Intra
ZNF366 Q8N895 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16125 ZNF326 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16129 ZNF346 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16131 ZNF365 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16132 ZNF367 Human Pre-designed siRNA Set A Pre-designed Set / Unkown