PINK1 - PTEN induced kinase 1 Gene

Also Known as BRPK; PARK6

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 65018

About PINK1

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,633,458-20,651,511 (from NCBI)

This gene has 3 transcripts (splice variants), 198 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 68.4), brain (RPKM 68.3) and 25 other tissues.

Summary

This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]

PINK1 Products (1)

mRNA	Protein	Name
NM_032409.3	NP_115785.1	serine/threonine-protein kinase PINK1, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	14607334	GOA
enables C3HC4-type RING finger domain binding	IPI IPI: Inferred from physical interaction	19880420	GOA
enables TORC2 complex binding	IPI IPI: Inferred from physical interaction	21177249	GOA
enables kinase activity	IDA IDA: Inferred from direct assay	15824318	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14607334	GOA
enables protease binding	IPI IPI: Inferred from physical interaction	21138942	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16632486	GOA
enables protein kinase B binding	IDA IDA: Inferred from direct assay	21177249	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	25527497	GOA
enables protein serine kinase activity	IMP IMP: Inferred from mutant phenotype	32484300	GOA
enables protein serine/threonine kinase activity	EXP EXP: Inferred from Experiment	24751536	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14607334	GOA
enables protein-containing complex binding	IMP IMP: Inferred from mutant phenotype	24270810	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	20798600	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in autophagy of mitochondrion	IMP IMP: Inferred from mutant phenotype	20798600	GOA
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	24553947	GOA
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	22764206	GOA
involved in establishment of protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	18957282	GOA
acts upstream of or within hemopoiesis	IGI IGI: Inferred from genetic interaction	33406421	GOA
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	14607334	GOA
involved in maintenance of protein location in mitochondrion	IMP IMP: Inferred from mutant phenotype	25527497	GOA
involved in mitochondrion organization	IMP IMP: Inferred from mutant phenotype	18560593	GOA
involved in mitochondrion to lysosome vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	24446486	GOA
involved in mitophagy	IDA IDA: Inferred from direct assay	38081847	GOA
involved in mitophagy	IGI IGI: Inferred from genetic interaction	33406421	GOA
involved in negative regulation of autophagosome assembly	IMP IMP: Inferred from mutant phenotype	19279012	GOA
involved in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	21177249	GOA
involved in negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	23261939	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15087508	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	17579517	GOA
involved in negative regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	19279012	GOA
involved in negative regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	19279012	GOA
involved in negative regulation of mitophagy	IMP IMP: Inferred from mutant phenotype	19279012	GOA
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18560593	GOA
involved in negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	16632486	GOA
involved in negative regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	18560593	GOA
involved in peptidyl-serine autophosphorylation	IMP IMP: Inferred from mutant phenotype	25527497	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	17579517	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	19880420	GOA
involved in positive regulation of cristae formation	IMP IMP: Inferred from mutant phenotype	19279012	GOA
involved in positive regulation of macroautophagy	IMP IMP: Inferred from mutant phenotype	20871098	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	21177249	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	24660806	GOA
involved in positive regulation of release of cytochrome c from mitochondria	IMP IMP: Inferred from mutant phenotype	19880420	GOA
involved in positive regulation of type 2 mitophagy	IMP IMP: Inferred from mutant phenotype	20871098	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14607334	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18957282	GOA
involved in protein stabilization	IMP IMP: Inferred from mutant phenotype	19229105	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	23933751	GOA
involved in regulation of cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	24446486	GOA
involved in regulation of mitochondrial membrane potential	IGI IGI: Inferred from genetic interaction	24475098	GOA
involved in regulation of mitochondrial membrane potential	IMP IMP: Inferred from mutant phenotype	18560593	GOA
involved in regulation of mitochondrion organization	IMP IMP: Inferred from mutant phenotype	21508222	GOA
involved in regulation of oxidative phosphorylation	IDA IDA: Inferred from direct assay	20871098	GOA
involved in regulation of protein targeting to mitochondrion	IGI IGI: Inferred from genetic interaction	21508222	GOA
involved in regulation of protein targeting to mitochondrion	IMP IMP: Inferred from mutant phenotype	23212910	GOA
involved in regulation of protein ubiquitination	IDA IDA: Inferred from direct assay	19880420	GOA
involved in regulation of protein ubiquitination	IMP IMP: Inferred from mutant phenotype	20871098	GOA
involved in regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	19880420	GOA
involved in regulation of reactive oxygen species metabolic process	IGI IGI: Inferred from genetic interaction	24475098	GOA
involved in regulation of reactive oxygen species metabolic process	IMP IMP: Inferred from mutant phenotype	21138942	GOA
involved in response to oxidative stress	IGI IGI: Inferred from genetic interaction	24475098	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in astrocyte projection	IDA IDA: Inferred from direct assay	16702191	GOA
located in axon	IDA IDA: Inferred from direct assay	16702191	GOA
located in cell body	IDA IDA: Inferred from direct assay	16702191	GOA
located in chromatin	IDA IDA: Inferred from direct assay	24798695	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16702191	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	24798695	GOA
located in cytosol	IDA IDA: Inferred from direct assay	18957282	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	31536960	GOA
located in membrane	IDA IDA: Inferred from direct assay	24798695	GOA
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	17579517	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	17579517	GOA
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	18687899	GOA
located in mitochondrial outer membrane	IMP IMP: Inferred from mutant phenotype	25527497	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	15087508	GOA
located in mitochondrion	IGI IGI: Inferred from genetic interaction	21355049	GOA
located in mitochondrion	IMP IMP: Inferred from mutant phenotype	24184327	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24798695	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16702191	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PINK1 Protein Structure

Pkinase

0
100
200
300
400
500
581 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase PINK1, mitochondrial	PTEN induced putative kinase 1

PINK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PINK1	Q9BXM7	FBXO7	Homo sapiens	Q9Y3I1	Pull Down	23933751
Intra	PINK1	Q9BXM7	FBXO7	Homo sapiens	Q9Y3I1	Anti Tag CoIP	23933751
Intra	PINK1	Q9BXM7	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	PINK1	Q9BXM7	HSP90AB1	Homo sapiens	P08238	Lumier	22939624
Intra	PINK1	Q9BXM7	MAP1LC3B	Homo sapiens	Q9GZQ8	IF	20153330
Intra	PINK1	Q9BXM7	MAP1LC3B	Homo sapiens	Q9GZQ8	Anti Bait CoIP	20153330
Intra	PINK1	Q9BXM7	MAP1LC3B	Homo sapiens	Q9GZQ8	Anti Tag CoIP	20153330
Intra	PINK1	Q9BXM7	SOCS4	Homo sapiens	Q8WXH5	Y2H Array	25814554
Intra	PINK1	Q9BXM7	PRKN	Homo sapiens	O60260	IF	20153330
Intra	PINK1	Q9BXM7	PRKN	Homo sapiens	O60260	Anti Tag CoIP	24357652
Intra	PINK1	Q9BXM7	PRKN	Homo sapiens	O60260	Pull Down	23933751
Intra	PINK1	Q9BXM7	FBXO7	Homo sapiens	Q9Y3I1-1	Anti Tag CoIP	23933751

Cross: Cross-species interaction Intra: Intraspecies interaction

PINK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84768	PINK1 Antibody (YA4465)	IHC-P, FC, ELISA	Human
HY-P84768A	PINK1 Antibody (YA4465)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Parkinson Disease 6, Autosomal Recessive Early-Onset	Autosomal Recessive Early-Onset Parkinson Disease 6 Parkinson Disease 6 PARK6 Parkinson Disease 6, Early Onset Parkinson'S Disease 6 Parkinson Disease 6, Early-Onset Autosomal Recessive Early-Onset Parkinson'S Disease 6 Early-Onset Parkinson Disease 6 Autosomal Recessive Early-Onset Parkinson Disease Type 6 Parkinson Disease 6 Early-Onset Parkinson Disease 6 Late-Onset Susceptibility To Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1 Parkinsonism Young Adult Onset Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1 Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset
Parkinson Disease 2, Autosomal Recessive Juvenile	Young-Onset Parkinson Disease PARK2 Pdj Autosomal Recessive Juvenile Parkinson Disease 2 Epdf Parkinson Disease, Juvenile, Type 2 Parkinson'S Disease 2 Autosomal Recessive Juvenile Parkinson Disease Early-Onset Parkinson Disease Parkinson Disease 2 Parkinson Disease, Juvenile, Autosomal Recessive Parkinsonism, Early-Onset, With Diurnal Fluctuation Autosomal Recessive Juvenile Parkinson'S Disease 2 Jp Juvenile Parkinsonism Parkinson Disease Autosomal Recessive, Early Onset Parkinsonism, Early Onset, With Diurnal Fluctuation Yopd Autosomal Recessive Early-Onset Parkinson Disease Type 2 Chromosome 6-Linked Autosomal Recessive Parkinsonism Early-Onset Parkinsonism With Diurnal Fluctuation Parkinsonism Young Adult Onset Parkinson Disease, Type 2 Parkinsonism, Juvenile
Parkinsonism	Parkinsonism-Plus Idiopathic Parkinsonism Primary Parkinsonism Paralysis Agitans Syndrome Parkinsonian Syndrome Trembling Paralysis Paralysis Agitans Shaking Palsy Shaking Paralysis
Movement Disease	Movement Disorders Movement Disorder
Early-Onset Parkinson'S Disease	Early-Onset Parkinson Disease
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Kufor-Rakeb Syndrome	Park9 Krppd KRS Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis And Dementia Autosomal Recessive Parkinson Disease 9 Parkinson Disease 9 Parkinson Disease 9, Autosomal Recessive, Juvenile-Onset Autosomal Recessive Juvenile Onset Parkinson Disease 9 Parkinson Disease Type 9 Pallidopyramidal Degeneration With Supranuclear Upgaze Paresis, And Dementia Park 9 Atp13a2-Related Juvenile Neuronal Ceroid Lipofuscinosis Cln12 Disease Juvenile Parkinsonism-Neuronal Ceroid Lipofuscinosis Parkinson Disease Autosomal Recessive 9
Parkinson Disease 15, Autosomal Recessive Early-Onset	Parkinsonian-Pyramidal Syndrome Pallidopyramidal Syndrome Parkinson Disease 15, Autosomal Recessive PARK15 Pkps Pallido-Pyramidal Syndrome Parkinson'S Disease 15 Autosomal Recessive Early-Onset Parkinson Disease 15 Autosomal Recessive Early-Onset Parkinson'S Disease 15 Pallido-Pyramidal Disease Parkinson Disease 15 Parkinson Disease 15 Autosomal Recessive Pps Parkinson Disease, Type 15
Dystonia 12	DYT12 Rdp Generalized Dystonia Dystonia-12 Rapid-Onset Dystonia-Parkinsonism Familial Dystonia Dystonia Musculorum Deformans Dystonic Disorders Idiopathic Familial Dystonia Dystonia-Parkinsonism, Rapid-Onset Fragments Of Torsion Dystonia Dyt-Atp1a3 Rapid-Onset Dystonia Parkinsonism Rodp Dystonia, Type 12 Dystonia 3, Torsion, X-Linked Idiopathic Non-Familial Dystonia Symptomatic Torsion Dystonia Dystonia Disorders
Postencephalitic Parkinson Disease	Postencephalitic Parkinsonism Parkinson Disease, Postencephalitic
Gaucher Disease, Type I	Glucocerebrosidase Deficiency Acid Beta-Glucosidase Deficiency Gba Deficiency GD1 Gd I Gaucher Disease, Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Type I Gaucher'S Disease Type I Gaucher Disease Gd 1 Non-Cerebral Juvenile Gaucher Disease GD Gaucher Disease 1 Adult Non-Neuronopathic Gaucher Disease Noncerebral Juvenile Gaucher Disease Type 1 Gaucher Disease Gaucher Disease, Type 1
Muscular Dystrophy, Congenital, Megaconial Type	Megaconial Type Congenital Muscular Dystrophy Congenital Megaconial Myopathy Congenital Muscular Dystrophy Due To Phosphatidylcholine Biosynthesis Defect Congenital Muscular Dystrophy With Mitochondrial Structural Abnormalities Megaconial Congenital Muscular Dystrophy MDCMC Muscular Dystrophy, Congenital, With Mitochondrial Structural Abnormalities Megaconial Congénital Muscular Dystrophy Dystrophy, Muscular, Congenital, Megaconial Type
Rem Sleep Behavior Disorder	Rapid Eye Movement Sleep Behavior Disorder Rem Sleep Behaviour Disorder Rapid Eye Movement Sleep Behaviour Disorder Rem - [Rapid Eye Movement] Behaviour Disorder
Vascular Parkinsonism
Dystonia	Dystonic Disease Dystonic Disorder Dystonia Disorders Neuroleptic Dyskinesia
Dementia, Lewy Body	Lewy Body Dementia Lewy Body Disease Diffuse Lewy Body Disease Dementia With Lewy Bodies DLB Autosomal Dominant Diffuse Lewy Body Disease Cortical Lewy Body Disease Dementia, Lewy Body, Susceptibility To Lewy Body Dementia, Susceptibility To Senile Dementia Of The Lewy Body Type Dementia Of The Lewy Body Type Lbd Diffuse Lewy Body Disease With Gaze Palsy Dysphasic Dementia Hereditary Lewy Body Type Senile Dementia Lewy Body Variant Of Alzheimer Disease Lewy Bodies Lewy Body Dlbd - [Diffuse Lewy Body Disease] Clbd - [Cortical Lewy Body Disease]
Multiple System Atrophy 1	Multiple System Atrophy Shy-Drager Syndrome Msa MSA1 Multiple System Atrophy 1, Susceptibility To Sporadic Olivopontocerebellar Atrophy Multisystem Atrophy Msa1, Susceptibility To Multiple System Atrophy, Susceptibility To Opca Progressive Autonomic Failure With Multiple System Atrophy Sds
Gaucher'S Disease	Gaucher Disease Kerasin Thesaurismosis Glucocerebrosidase Deficiency Glucosylceramidase Deficiency Cerebroside Lipidosis Syndrome Acid Beta-Glucosidase Deficiency Glucosylceramide Beta-Glucosidase Deficiency Acute Cerebral Gaucher Disease Gaucher Splenomegaly Glucocerebrosidosis Glucosyl Cerebroside Lipidosis Kerasin Lipoidosis Lipoid Histiocytosis Glocucerebrosidase Deficiency Sphingolipidosis 1 Gaucher Syndrome Gauchers Disease Gd Glucosylceramide Lipidosis Kerasin Histiocytosis Gaucher Disease, Type 1 Gaucher Disease, Type 2
Sphingolipidosis	Sphingolipidoses
Toxic Encephalopathy	Neurotoxicity Neurotoxicity Syndromes Neurotoxicity Syndrome Encephalopathy, Toxic
Supranuclear Palsy, Progressive, 1	Progressive Supranuclear Palsy Steele-Richardson-Olszewski Syndrome Supranuclear Palsy, Progressive Progressive Supranuclear Ophthalmoplegia Psp PSNP1 Familial Progressive Supranuclear Palsy Richardson'S Syndrome Psp Syndrome Progressive Supranuclear Palsy 1 Supranuclear Palsy Progressive Ophthalmoplegia, Supranuclear, Progressive Steele-Richardson-Olszewksi Syndrome
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Optic Nerve Disease	Optic Neuropathy Disorder Of The Second Nerve Optic Nerve Disorder Optic Nerve Abnormality Of The Optic Nerve Optic Nerve Disorders Neuropathy, Optic Disorder Of The Optic Nerve
Neurodegeneration With Brain Iron Accumulation	Nbia Neurodegeneration With Brain Iron Accumulation Disorders Neurodegeneration, With Brain Iron Accumulation
Mitochondrial Complex I Deficiency, Nuclear Type 1	Mitochondrial Complex I Deficiency Nadh:Q(1) Oxidoreductase Deficiency MC1DN1 Nadh-Coenzyme Q Reductase Deficiency Isolated Mitochondrial Respiratory Chain Complex I Deficiency Isolated Nadh-Coenzyme Q Reductase Deficiency Isolated Nadh-Coq Reductase Deficiency Isolated Nadh-Ubiquinone Reductase Deficiency Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of Nuclear Type Mitochondrial Complex I Deficiency 1 Isolated Complex I Deficiency Complex 1 Mitochondrial Respiratory Chain Deficiency Nadh Coenzyme Q Reductase Deficiency Complex I Mitochondrial Respiratory Chain Deficiency Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I Nadh:Ubiquinone Oxidoreductase Deficiency Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Leber Hereditary Optic Neuropathy, Modifier Of	Leber Optic Atrophy Leber Hereditary Optic Neuropathy LHON Leber'S Hereditary Optic Neuropathy Leber Optic Atrophy, Susceptibility To Leber'S Optic Atrophy LOAM Loas Leber'S Disease Leber'S Optic Neuropathy Optic Atrophy, Hereditary, Leber Lhon, Modifier Of Optic Atrophy, Leber Type Hereditary Optic Neuroretinopathy Leber Hereditary Optic Atrophy Loa Optic Atrophy Leber Type Leber Hereditary Optic Neuropathy, Modifier Leber Hereditary Optic Neuropathy Susceptibility Modifier Of Leber Hereditary Optic Neuropathy Lebers Hereditary Optic Neuropathy Leber Congenital Amaurosis
Choreatic Disease	Chorea Hereditary Chorea
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Neuronal Ceroid Lipofuscinosis	Hereditary Ceroid Lipofuscinosis Batten Disease Ncl Neuronal Ceroid-Lipofuscinoses Lipofuscinosis, Ceroid, Neuronal Juvenile Neuronal Ceroid Lipofuscinosis Cerebromacular Dystrophy Cerebromacular Degeneration Ceroid-Lipofuscinosis Ncl - [Neuronal Ceroid Lipofuscinosis] Amaurotic Familial Idiocy Amaurotic Idiocy Amaurotic Idiot Neuronal Lipofuscinosis Pigmentary Retinal Lipoid Neuronal Heredodegeneration
Mitochondrial Myopathy	Mitochondrial Myopathies Mitochondrial Cytopathy Myopathies In Mitochondrial Disorders
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Pick Disease Of Brain	Pick Disease Pick'S Disease Pick Disease Of The Brain Lobar Atrophy Of Brain Dementia With Lobar Atrophy And Neuronal Cytoplasmic Inclusions Behavioral Variant Of Frontotemporal Dementia Dementia In Pick'S Disease Lobar Atrophy Of The Brain Bvftd Bv-Ftd PIDB Picks Disease
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia
Leigh Syndrome	Leigh Disease Infantile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Iv Deficiency LS Sne Leigh'S Disease Leigh Syndrome Due To Mitochondrial Complex I Deficiency Necrotizing Encephalopathy, Infantile Subacute, Of Leigh Subacute Necrotizing Encephalomyelopathy Necrotizing Encephalopathy Infantile Subacute Of Leigh Leigh Syndrome Due To Mitochondrial Complex Iii Deficiency Infantile Necrotizing Encephalomyelopathy Juvenile Subacute Necrotizing Encephalomyelopathy Leigh'S Necrotizing Encephalopathy Subacute Necrotizing Encephalopathy Juvenile Subacute Necrotizing Encephalopathy Leigh Syndrome Due To Mitochondrial Complex Ii Deficiency Leigh Syndrome Due To Mitochondrial Complex V Deficiency Encephalopathy, Subacute Necrotizing, Infantile Encephalopathy, Subacute Necrotizing, Juvenile Maternally Inherited Leigh Syndrome Subacute Necrotising Encephalomyelopathy Subacute Necrotising Encephalopathy
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17355B	Dexpramipexole	Activator	99.56%	Yes

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15887	MG 149	Inhibitor	99.60%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PINK1	VGNC	VGNC:100036
Bos taurus	PINK1	VGNC	VGNC:32904
Canis familiaris	PINK1	VGNC	VGNC:44567
Rattus norvegicus	PINK1	RGD	RGD:1305769
Felis catus	PINK1	VGNC	VGNC:64180
Mus musculus	PINK1	MGD	MGI:1916193
Others	PINK1	NCBI