2. Gene
  3. SOCS4 - suppressor of cytokine signaling 4 Gene

SOCS4 - suppressor of cytokine signaling 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as SOCS7

Gene ID: 122809 | Gene type: protein coding

About SOCS4

Cytogenetic location: 14q22.3 Genomic coordinates (GRCh38): 14:55,027,236-55,049,489 (from NCBI)

This gene has 4 transcripts (splice variants), 263 orthologues and 7 paralogues. Ubiquitous expression in appendix (RPKM 5.4), lymph node (RPKM 5.2) and 25 other tissues.

Summary

The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS), also known as STAT-induced STAT Inhibitor (SSI), protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SOCS4 Products(2)

mRNA Protein Name
NM_080867.3 NP_543143.1 suppressor of cytokine signaling 4
NM_199421.2 NP_955453.1 suppressor of cytokine signaling 4
Protein Preferred Names Protein Names

suppressor of cytokine signaling 4

SH2 domain containing SOCS box protein

Related Diseases

Diseases Alias
Borderline Glaucoma

Preglaucoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13555 SOCS4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SOCS4 RGD RGD:1306503
Bos taurus SOCS4 VGNC VGNC:35122
Macaca mulatta SOCS4 VGNC VGNC:77741
Felis catus SOCS4 VGNC VGNC:80837
Mus musculus SOCS4 MGD MGI:1914546
Canis familiaris SOCS4 VGNC VGNC:46651