FRS3 - fibroblast growth factor receptor substrate 3 Gene

Homo sapiens

Also known as SNT2; FRS2B; SNT-2; FRS2beta; FRS2-beta

Gene ID: 10817 | Gene type: protein coding

About FRS3

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:41,770,176-41,779,900 (from NCBI)

This gene has 5 transcripts (splice variants), 205 orthologues and 7 paralogues. Broad expression in testis (RPKM 6.0), brain (RPKM 2.3) and 23 other tissues.

Summary

This gene encodes a substrate for the Fibroblast Growth Factor receptor. The encoded protein is found in the peripheral plasma membrane and links Fibroblast Growth Factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]

FRS3 Products(1)

mRNA	Protein	Name
NM_006653.5	NP_006644.1	fibroblast growth factor receptor substrate 3

FRS3 Protein Structure

IRS

0
100
200
300
400
492 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor receptor substrate 3

FGFR substrate 3

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05113	FRS3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FRS3	VGNC	VGNC:29121
Macaca mulatta	FRS3	VGNC	VGNC:72731
Mus musculus	FRS3	MGD	MGI:2135965
Rattus norvegicus	FRS3	RGD	RGD:1310226
Felis catus	FRS3	VGNC	VGNC:62369
Canis familiaris	FRS3	VGNC	VGNC:40987