ID2 - inhibitor of DNA binding 2 Gene

Also Known as GIG8; ID2A; ID2H; bHLHb26

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3398

About ID2

Cytogenetic location: 2p25.1 Genomic coordinates (GRCh38): 2:8,682,056-8,684,461 (from NCBI)

This gene has 4 transcripts (splice variants), 205 orthologues and 3 paralogues. Ubiquitous expression in liver (RPKM 128.2), bone marrow (RPKM 111.2) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the inhibitor of DNA binding family, members of which are transcriptional regulators that contain a helix-loop-helix (HLH) domain but not a basic domain. Members of the inhibitor of DNA binding family inhibit the functions of basic helix-loop-helix transcription factors in a dominant-negative manner by suppressing their heterodimerization partners through the HLH domains. This protein may play a role in negatively regulating cell differentiation. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Aug 2011]

ID2 Products (1)

mRNA	Protein	Name
NM_002166.5	NP_002157.2	DNA-binding protein inhibitor ID-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10915743	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16311606	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14627819	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	14627819	GOA
acts upstream of regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16311606	GOA
involved in regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16311606	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with cytoplasm	IDA IDA: Inferred from direct assay	16311606	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20861012	GOA
located in cytosol	IDA IDA: Inferred from direct assay	16311606	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16311606	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ID2 Protein Structure

HLH

0
100
134 a.a.

Protein Preferred Names	Protein Names
DNA-binding protein inhibitor ID-2	DNA-binding protein inhibitor ID2

ID2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ID2	Q02363	ASCL4	Homo sapiens	Q6XD76	Validated Y2H	32296183
Intra	ID2	Q02363	PRKCA	Homo sapiens	P17252	Y2H Array	32814053
Intra	ID2	Q02363	PRKCA	Homo sapiens	P17252	Y2H Pooling	32814053
Intra	ID2	Q02363	PRKCA	Homo sapiens	P17252	Validated Y2H	32814053
Intra	ID2	Q02363	FANCL	Homo sapiens	Q9NW38	Validated Y2H	32296183
Intra	ID2	Q02363	FGFR1	Homo sapiens	P11362-2	Validated Y2H	32814053
Intra	ID2	Q02363	FGFR1	Homo sapiens	P11362-2	Y2H Array	32814053
Intra	ID2	Q02363	FGFR1	Homo sapiens	P11362-2	Y2H Pooling	32814053
Intra	ID2	Q02363	PPIA	Homo sapiens	P62937-2	Validated Y2H	32814053
Intra	ID2	Q02363	PPIA	Homo sapiens	P62937-2	Y2H Pooling	32814053
Intra	ID2	Q02363	PPIA	Homo sapiens	P62937-2	Y2H Array	32814053
Intra	ID2	Q02363	PPIB	Homo sapiens	P23284	Y2H Array	32814053
Intra	ID2	Q02363	PPIB	Homo sapiens	P23284	Y2H Pooling	32814053
Intra	ID2	Q02363	PPIB	Homo sapiens	P23284	Validated Y2H	32814053
Intra	ID2	Q02363	YWHAG	Homo sapiens	P61981	Y2H Pooling	32814053
Intra	ID2	Q02363	YWHAG	Homo sapiens	P61981	Validated Y2H	32814053
Intra	ID2	Q02363	YWHAG	Homo sapiens	P61981	Y2H Array	32814053
Intra	ID2	Q02363	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	ID2	Q02363	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	ID2	Q02363	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	ID2	Q02363	KAT5	Homo sapiens	Q92993	Y2H Pooling	32814053
Intra	ID2	Q02363	KAT5	Homo sapiens	Q92993	Validated Y2H	32814053
Intra	ID2	Q02363	KAT5	Homo sapiens	Q92993	Y2H Array	32814053
Intra	ID2	Q02363	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ID2	Q02363	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ID2	Q02363	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ID2	Q02363	HTRA2	Homo sapiens	O43464	Y2H Array	32814053
Intra	ID2	Q02363	HTRA2	Homo sapiens	O43464	Validated Y2H	32814053
Intra	ID2	Q02363	HTRA2	Homo sapiens	O43464	Y2H Pooling	32814053
Intra	ID2	Q02363	TCF4	Homo sapiens	P15884	Y2H	16549780
Intra	ID2	Q02363	TCF4	Homo sapiens	P15884	Anti Tag CoIP	33961781
Intra	ID2	Q02363	TCF4	Homo sapiens	P15884	Anti Tag CoIP	28514442
Intra	ID2	Q02363	TCF12	Homo sapiens	Q99081	Anti Tag CoIP	33961781
Intra	ID2	Q02363	TCF12	Homo sapiens	Q99081	Anti Bait CoIP	19321746
Intra	ID2	Q02363	TCF12	Homo sapiens	Q99081	Y2H	16549780
Intra	ID2	Q02363	C22orf39	Homo sapiens	Q6P5X5	Validated Y2H	32296183
Intra	ID2	Q02363	TCHP	Homo sapiens	Q9BT92	Validated Y2H	32296183
Intra	ID2	Q02363	ENKD1	Homo sapiens	Q9H0I2	Validated Y2H	32296183
Intra	ID2	Q02363	FNDC11	Homo sapiens	Q9BVV2	Validated Y2H	32296183
Intra	ID2	Q02363	CCNDBP1	Homo sapiens	O95273	Anti Tag CoIP	22453338
Intra	ID2	Q02363	PDLIM5	Homo sapiens	Q96HC4	Y2H	16549780
Intra	ID2	Q02363	TCF3	Homo sapiens	P15923	Anti Tag CoIP	33961781
Intra	ID2	Q02363	TCF3	Homo sapiens	P15923	Anti Bait CoIP	19321746
Intra	ID2	Q02363	TCF3	Homo sapiens	P15923-1	Y2H	10915743
Intra	ID2	Q02363	TCF3	Homo sapiens	P15923-1	Pull Down	10915743
Intra	ID2	Q02363	PKD2	Homo sapiens	Q13563	Confocal	16311606
Intra	ID2	Q02363	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	ID2	Q02363	HLA-A	Homo sapiens	Q5SUL5	Validated Y2H	32814053
Intra	ID2	Q02363	HLA-A	Homo sapiens	Q5SUL5	Y2H Array	32814053
Intra	ID2	Q02363	HLA-A	Homo sapiens	Q5SUL5	Y2H Pooling	32814053
Intra	ID2	Q02363	SETDB1	Homo sapiens	Q15047-2	Validated Y2H	32814053
Intra	ID2	Q02363	SETDB1	Homo sapiens	Q15047-2	Y2H Array	32814053
Intra	ID2	Q02363	SETDB1	Homo sapiens	Q15047-2	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

ID2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84471	ID2 Antibody (YA4168)	IHC-P, FC, ELISA	Human
HY-P84471A	ID2 Antibody (YA4168)(PBS only)	IHC-P, FC, ELISA	Human

Related Diseases

Diseases	Alias
Retinoblastoma	RB Trilateral Retinoblastoma RB1 Retinoblastoma, Trilateral Neuroblastoma Of Retina Rb - Retinoblastoma Eye Cancer, Retinoblastoma Retinal Cancer Retinal Tumor Glioma, Retinal Non-Hereditary Retinoblastoma Childhood Cancer Retinoblastoma Malignant Neoplasm Of Retina Retinal Neoplasms
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Burkitt Lymphoma	Burkitt'S Lymphoma BL Burkitt Lymphoma, Somatic Burkitt Lymphoma/Leukaemia Burkitt'S Tumor Burkitt'S Tumor Or Lymphoma Malignant Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma, Burkitt'S Type Small Non-Cleaved Cell Lymphoma Burkitt Tumor Burkitts Lymphoma Lymphoma, Small Noncleaved-Cell Burkitt Tumour Diffuse Small Noncleaved Malignant Burkitt Lymphoma Malignant Burkitt Lymphoma “Burkitt-Like” Lymphoma Undifferentiated Burkitt Lymphoma Small Noncleaved Cell Burkitt Lymphoma
Intellectual Developmental Disorder, Autosomal Dominant 1	MRD1 Autosomal Dominant Non-Syndromic Intellectual Disability 1 Mental Retardation, Autosomal Dominant 1 Autosomal Dominant Intellectual Developmental Disorder 1
Rett Syndrome	Atypical Rett Syndrome RTT Rett Disorder Rts Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use Rett Syndrome, Preserved Speech Variant Rett Syndrome, Atypical Rett'S Disorder Rett Syndrome Variant Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome Cerebroatrophic Hyperammonemia Rett Like Syndrome Rett'S Syndrome Atypical Rtt Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Rett Syndrome Preserved Speech Variant Rett Syndrome Zappella Variant Rett Syndrome, Zappella Variant
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N4058	Helichrysetin	Inducer	99.86%	Unkown
HY-144707	AK-778-XXMU		99.96%	Unkown
HY-119966	CCT036477	Inhibitor	99.42%	Unkown
HY-155705	BMP agonist 1		/	Unkown
HY-RS06523	ID2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17244	Id2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23698	Id2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ID2	VGNC	VGNC:59229
Rattus norvegicus	ID2	RGD	RGD:2859
Macaca mulatta	ID2	VGNC	VGNC:97777
Felis catus	ID2	VGNC	VGNC:97461
Mus musculus	ID2	MGD	MGI:96397
Others	ID2	NCBI