PKD2 - polycystin 2, transient receptor potential cation channel Gene

Also Known as PC2; PKD4; Pc-2; APKD2; TRPP2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5311

About PKD2

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:88,007,635-88,077,777 (from NCBI)

This gene has 7 transcripts (splice variants), 222 orthologues, 10 paralogues and is associated with 2 phenotypes. Ubiquitous expression in endometrium (RPKM 27.5), kidney (RPKM 19.2) and 25 other tissues.

Summary

This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011]

PKD2 Products (5)

mRNA	Protein	Name
XM_011532028.3	XP_011530330.1	polycystin-2 isoform X1
NM_000297.4	NP_000288.1	polycystin-2
XM_011532030.3	XP_011530332.1	polycystin-2 isoform X3
XM_011532029.2	XP_011530331.1	polycystin-2 isoform X2
NR_156488.2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables HLH domain binding	IPI IPI: Inferred from physical interaction	16311606	GOA
enables actinin binding	IDA IDA: Inferred from direct assay	15843396	GOA
contributes to calcium channel activity	IDA IDA: Inferred from direct assay	27214281	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	24990821	GOA
enables calcium-induced calcium release activity	IDA IDA: Inferred from direct assay	11854751	GOA
enables cytoskeletal protein binding	IDA IDA: Inferred from direct assay	10760273	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19556541	GOA
enables monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	29899465	GOA
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	19801576	GOA
enables potassium channel activity	IDA IDA: Inferred from direct assay	26269590	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9171830	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	9192675	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	16223735	GOA
enables transcription regulator inhibitor activity	IPI IPI: Inferred from physical interaction	16311606	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	10097141	GOA
enables voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	11252306	GOA
enables voltage-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	11252306	GOA
enables voltage-gated monoatomic ion channel activity	IDA IDA: Inferred from direct assay	11854751	GOA
enables voltage-gated potassium channel activity	IMP IMP: Inferred from mutant phenotype	27071085	GOA
enables voltage-gated sodium channel activity	IDA IDA: Inferred from direct assay	11252306	GOA
enables voltage-gated sodium channel activity	IMP IMP: Inferred from mutant phenotype	27071085	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt signaling pathway	IDA IDA: Inferred from direct assay	27214281	GOA
involved in aorta development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in branching involved in ureteric bud morphogenesis	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	11854751	GOA
involved in calcium ion transport	IDA IDA: Inferred from direct assay	11252306	GOA
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	27214281	GOA
involved in cellular response to cAMP	IMP IMP: Inferred from mutant phenotype	26269590	GOA
involved in cellular response to fluid shear stress	IMP IMP: Inferred from mutant phenotype	19265036	GOA
involved in cellular response to hydrostatic pressure	IDA IDA: Inferred from direct assay	16025301	GOA
involved in cellular response to osmotic stress	IDA IDA: Inferred from direct assay	16025301	GOA
acts upstream of or within cilium organization	IMP IMP: Inferred from mutant phenotype	28154160	GOA
involved in determination of liver left/right asymmetry	IMP IMP: Inferred from mutant phenotype	21719175	GOA
involved in heart development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in heart looping	IMP IMP: Inferred from mutant phenotype	21719175	GOA
involved in inorganic cation transmembrane transport	IMP IMP: Inferred from mutant phenotype	29899465	GOA
involved in liver development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in mesonephric duct development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in mesonephric tubule development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric S-shaped body morphogenesis	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric ascending thin limb development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric cortex development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric cortical collecting duct development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric distal tubule development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric mesenchyme development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric part of ureteric bud development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in metanephric smooth muscle tissue development	IEP IEP: Inferred from expression pattern	11891195	GOA
acts upstream of negative regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	16311606	GOA
involved in neural tube development	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity	IMP IMP: Inferred from mutant phenotype	16223735	GOA
involved in positive regulation of nitric oxide biosynthetic process	IMP IMP: Inferred from mutant phenotype	19265036	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16311606	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	9192675	GOA
involved in potassium ion transmembrane transport	IDA IDA: Inferred from direct assay	26269590	GOA
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	27071085	GOA
involved in protein heterotetramerization	IDA IDA: Inferred from direct assay	30093605	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	28092368	GOA
involved in protein tetramerization	IDA IDA: Inferred from direct assay	29899465	GOA
involved in regulation of calcium ion import	IDA IDA: Inferred from direct assay	11854751	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15001556	GOA
involved in release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	11854751	GOA
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	19265036	GOA
involved in renal artery morphogenesis	IEP IEP: Inferred from expression pattern	11891195	GOA
involved in sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	11252306	GOA
involved in sodium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	27071085	GOA
involved in spinal cord development	IEP IEP: Inferred from expression pattern	11891195	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in basal cortex	IDA IDA: Inferred from direct assay	10770959	GOA
located in basal plasma membrane	IDA IDA: Inferred from direct assay	10770959	GOA
part of cation channel complex	IDA IDA: Inferred from direct assay	30093605	GOA
located in ciliary basal body	IDA IDA: Inferred from direct assay	15337773	GOA
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10770959	GOA
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	16311606	GOA
located in cytoplasmic side of endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21044049	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	10760273	GOA
located in endoplasmic reticulum	IMP IMP: Inferred from mutant phenotype	16223735	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11854751	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	37681898	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	10760273	GOA
located in lumenal side of endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21044049	GOA
located in membrane	IDA IDA: Inferred from direct assay	30093605	GOA
located in migrasome	IDA IDA: Inferred from direct assay	37681898	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	15123714	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15692563	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	27071085	GOA
part of polycystin complex	IPI IPI: Inferred from physical interaction	11901144	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PKD2 Protein Structure

PKD_channel

0
200
400
600
800
968 a.a.

Protein Preferred Names	Protein Names
polycystin-2	autosomal dominant polycystic kidney disease type II protein polycystic kidney disease 2 (autosomal dominant) transient receptor potential cation channel subfamily P member 2

PKD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	PKD2	Q13563	Trpc3	Mus musculus	Q9QZC1	Anti Tag CoIP	19812035
Intra	PKD2	Q13563	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	PKD2	Q13563	MAGEA8	Homo sapiens	P43361	Validated Y2H	25416956
Intra	PKD2	Q13563	MAGEA8	Homo sapiens	P43361	Y2H Array	29892012
Intra	PKD2	Q13563	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	PKD2	Q13563	KRTAP6-2	Homo sapiens	Q3LI66	Validated Y2H	32296183
Intra	PKD2	Q13563	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	PKD2	Q13563	PKD1	Homo sapiens	P98161	NMR	20168298
Intra	PKD2	Q13563	PKD1	Homo sapiens	P98161	Pull Down	20168298
Intra	PKD2	Q13563	PKD1	Homo sapiens	P98161	Anti Tag CoIP	20168298
Intra	PKD2	Q13563	PKD1	Homo sapiens	P98161	Y2H	20168298
Intra	PKD2	Q13563	PKD1	Homo sapiens	P98161-1	GMS	30093605
Intra	PKD2	Q13563	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	PKD2	Q13563	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Cross	PKD2	Q13563	Hax1	Mus musculus	O35387	Anti Tag CoIP	10760273
Cross	PKD2	Q13563	Hax1	Mus musculus	O35387	Y2H	10760273
Cross	PKD2	Q13563	Trpv4	Mus musculus	Q9EPK8	Anti Bait CoIP	25114176
Cross	PKD2	Q13563	Trpv4	Mus musculus	Q9EPK8	Confocal	25114176
Intra	PKD2	Q13563	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	PKD2	Q13563	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	PKD2	Q13563	ID2	Homo sapiens	Q02363	Y2H	16311606
Intra	PKD2	Q13563	ID2	Homo sapiens	Q02363	Anti Bait CoIP	16311606
Intra	PKD2	Q13563	ID2	Homo sapiens	Q02363	Anti Tag CoIP	16311606
Intra	PKD2	Q13563	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	PKD2	Q13563	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	PKD2	Q13563	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	PKD2	Q13563	PLSCR1	Homo sapiens	O15162	Y2H Array	25416956
Intra	PKD2	Q13563	TRPC1	Homo sapiens	P48995	Anti Bait CoIP	25114176
Intra	PKD2	Q13563	TRPC1	Homo sapiens	P48995	Confocal	25114176
Intra	PKD2	Q13563	TRPC1	Homo sapiens	P48995	Pull Down	10097141
Intra	PKD2	Q13563	PKD2	Homo sapiens	Q13563	Y2H	20168298
Intra	PKD2	Q13563	PKD2	Homo sapiens	Q13563	Solution Sedimentation	20168298
Intra	PKD2	Q13563	PKD2	Homo sapiens	Q13563	Pull Down	20168298
Intra	PKD2	Q13563	PKD2	Homo sapiens	Q13563	GMS	27768895
Intra	PKD2	Q13563	PKD2	Homo sapiens	Q13563	3D-EM	27768895
Intra	PKD2	Q13563	PKD2	Homo sapiens	Q13563	Comig Non-Denat Gel	20168298
Intra	PKD2	Q13563	PKD2	Homo sapiens	Q13563	Anti Tag CoIP	20168298
Intra	PKD2	Q13563	PKD2	Homo sapiens	Q13563	Crosslink	20168298
Intra	PKD2	Q13563	PKD2	Homo sapiens	Q13563	3D-EM	28092368
Intra	PKD2	Q13563	TRPC1	Homo sapiens	P48995-2	Pull Down	10097141
Intra	PKD2	Q13563	TRPC1	Homo sapiens	P48995-2	Anti Tag CoIP	10097141

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Nephronophthisis 3	NPHP3 Nph3 Adolescent Nephronophthisis Nephronophthisis, Type 3
Visceral Heterotaxy	Situs Ambiguus Heterotaxia Heterotaxy Syndrome Heterotaxy Lateralization Defect Situs Ambiguous Left Isomerism Htx Ivemark Syndrome Right Isomerism Situs Ambiguus Viscerum Incomplete Situs Inversus Partial Situs Inversus Heterotaxy, Visceral Asplenia Syndrome Bilateral Left-Sidedness Polysplenia Syndrome Moller Syndrome
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease	PKD3 Polycystic Kidney Disease, Adult, Type Iii Apkd3 Polycystic Kidney Disease 3 Polycystic Kidney Disease, Type 3 Polycystic Kidney Disease 3 Without Polycystic Liver Disease Polycystic Kidney Disease 3, Autosomal Dominant
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease	Autosomal Recessive Polycystic Kidney Disease Arpkd Polycystic Kidney Disease, Autosomal Recessive Polycystic Kidney And Hepatic Disease 1 Pkhd1 PKD4 Polycystic Kidney Disease 4 With Or Without Hepatic Disease Polycystic Kidney Disease, Infantile, Type I Polycystic Kidney Disease, Infantile Type Polycystic Kidney, Autosomal Recessive Pkd3, Formerly Polycystic Kidney Disease 4, With Or Without Hepatic Disease Arpkd/Chf Ar-Pkd Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease Infantile Polycystic Kidney Disease Type I Pkd3 Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease Polycystic Kidney Disease 3, Autosomal Dominant
Parastremmatic Dwarfism	Parastremmatic Dysplasia PSTD Dwarfism, Parastremmatic
Polycystic Liver Disease	Autosomal Dominant Polycystic Liver Disease Isolated Polycystic Liver Disease Pcld Congenital Cystic Liver Disease Congenital Hepatic Cyst Fibrocystic Liver Disease Isolated Autosomal Dominant Polycystic Liver Disease Adpcld Liver Disease, Polycystic Multiple Cysts Of Liver Pld - [Polycystic Liver Disease] Polycystic Liver Disorder Polycystic Liver Congenital Polycystic Disease Of Liver Congenital Polycystic Liver Disease
Chronic Kidney Disease	Chronic Renal Disease Chronic Kidney Failure Ckd Chronic Renal Failure Kidney Failure, Chronic Chronic Renal Failure Syndrome Crf Renal Failure - Chronic Renal Failure Chronic Chronic Kidney Diseases Chronic Kidney Disease Stage 5 Ckd - [Chronic Kidney Disease] Crf - [Chronic Renal Failure] Chronic Kidney Impairment Chronic Renal Impairment Chronic Kidney Shutdown Chronic Hypoxic Kidney Failure Chronic Kidney Collapse Chronic Renal Insufficiency Chronic Kidney Toxaemia Chronic Kidney Hypofunction Chronic Renal Suppression Chronic Renal Failure, Stage 5 Ckd - [Chronic Kidney Disease] Stage 5 End Stage Kidney Failure End Stage Renal Failure End Stage Kidney Disease End Stage Renal Disease End Stage Chronic Renal Failure Esrf - [End Stage Renal Failure] Esrd - [End Stage Renal Diseases] Egfr - [Estimated Glomerular Filtration Rate] < 15 Ml/Min/1.73m²
Cystic Kidney Disease	Renal Cyst Simple Renal Cyst Kidney Cysts Kidney Diseases, Cystic Renal Cysts Kidney Cyst Cystic Kidney Congenital Cystic Kidney Disease Cystic Kidney Diseases Bosniak 1 Cyst
End Stage Renal Disease	End Stage Renal Failure End-Stage Kidney Disease Kidney Failure, Chronic Chronic Kidney Disease Stage 5
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 2 PKD2 Polycystic Kidney Disease, Adult, Type Ii Apkd2 Polycystic Kidney Disease, Type 2 Adpkd2 Adult Polycystic Kidney Disease Type 2 Autosomal Dominant Polycystic Kidney Disease 2 Pkd-2 Polycystic Kidney Disease Adult Type Ii Polycystic Kidney Type 2 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 2
Kartagener Syndrome	Kartagener'S Syndrome
Nephronophthisis	Medullary Cystic Disease Medullary Cystic Kidney Nph Nphp Kidney Disease, Cystic, Medullary
Chromosome 2q35 Duplication Syndrome	Syndactyly Syndactyly Type 1 Sdty1 Syndactyly, Type I Sd1 Zygodactyly Syndactyly, Type 1, With Or Without Craniosynostosis Non-Syndromic Syndactyly Symphalangism Symphalangy Webbing Of Digits Syndactyly, Type 1
Caroli Disease	Caroli Disease Isolated Congenital Polycystic Dilatation Of Intrahepatic Bile Ducts Cystic Dilatation Of The Intrahepatic Biliary Tree Caroli Syndrome Carolis Disease
Polycystic Liver Disease 1 With Or Without Kidney Cysts	Polycystic Liver Disease 1 PCLD1 Liver Disease, Polycystic, Type 1 Polycystic Liver Disease Cyst
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Meckel Syndrome, Type 1	Meckel Syndrome Meckel-Gruber Syndrome Dysencephalia Splanchnocystica Meckel Syndrome 1 MKS1 Mks Gruber Syndrome Meckel-Gruber Syndrome, Type 1 Mes Dysencephalia Splachnocystica Meckel Gruber Syndrome Meckel Syndrome Type 1
Multicystic Dysplastic Kidney	Multicystic Renal Dysplasia Multicystic Kidney Dysplasia Mcdk Multiple Congenital Cysts Of Kidney Developmental Multicystic Kidney
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Cavernous Angioma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Contractures, Pterygia, And Spondylocarpotarsal Fusion Syndrome 1a	Multiple Pterygium Syndrome, Autosomal Dominant CPSFS1A Contractures, Pterygia, And Spondylocarpostarsal Fusion Syndrome 1a Autosomal Dominant Disease Contractures, Pterygia, And Variable Skeletal Fusions Syndrome 1a Cpskf1a Pterygium Syndrome, Multiple Autosomal Dominant Arthrogryposis, Distal, Type 8, Formerly Da8, Formerly Autosomal Dominant Multiple Pterygium Syndrome Distal Arthrogryposis Type 8 Arthrogryposis, Distal, Type 8 Da8 Pterygium Syndrome, Multiple, Autosomal Dominant Autosomal Dominant Disorder
Autosomal Genetic Disease	Autosomal Hereditary Disorder
Cranioectodermal Dysplasia	Sensenbrenner Syndrome Levin Syndrome 1 Ced Levin Syndrome Dysplasia, Cranioectodermal
Prostatic Cyst	Cyst Of Prostate
Asphyxiating Thoracic Dystrophy	Jeune Thoracic Dystrophy Jeune Syndrome Asphyxiating Thoracic Dysplasia Short-Rib Thoracic Dysplasia With Or Without Polydactyly Thoracic Pelvic Phalangeal Dystrophy Asphyxiating Thoracic Chondrodystrophy Atd Chondroectodermal Dysplasia-Like Syndrome Infantile Thoracic Dystrophy Jeune Thoracic Dysplasia Thoracic Asphyxiant Dystrophy Thoracic-Pelvic-Phalangeal Dystrophy Short-Rib Thoracic Dysplasia Without Polydactyly Asphyxiating Thoracic Dystrophy Of The Newborn Asphyxiating Thorax Dystrophy
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Liver Disease	Liver Failure Liver Diseases Abnormality Of The Liver Liver Dysfunction Disorder Of Liver Hepatic Disorder Hepatic Disease Disease Of Bilirubin Metabolism Disorder Of Bilirubin Metabolism Liver Decompensation Liver Function Failure Hepatic Failure Nos Liver Failure Nos End Stage Liver Disease Decompensated Liver Failure Decompensation Of Liver Function Hepatic Decompensation Hepatic Insufficiency Liver Cell Necrosis With Hepatic Failure Liver Insufficiency Decompensated Liver Disease End Stage Liver Failure Liver Necrosis With Hepatic Failure
Septal Myocardial Infarction
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 1 PKD1 Adpkd Polycystic Kidney Disease, Adult, Type I Apkd1 Potter Type Iii Polycystic Kidney Disease Polycystic Kidney Disease, Adult Potter Type Iii Polycystic Kidney Disease, Formerly Polycystic Kidney Disease, Type 1 Adpkd1 Adult Polycystic Kidney Disease Type 1 Autosomal Dominant Polycystic Kidney Disease 1 Pkd-1 Polycystic Kidney Disease Adult Polycystic Kidney Disease Type I Polycystic Kidneys Polycystic Kidney Disease, Adult Type I Polycystic Kidney Type 1 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 1 Polycystic Kidney, Autosomal Dominant Polycystic Kidney, Type 1 Autosomal Dominant Disease Polycystic Kidney Diseases
Mucolipidosis Iv	Mucolipidosis Type Iv ML4 Sialolipidosis Mucolipidosis Type 4 Ganglioside Sialidase Deficiency Mliv Ml Iv Berman Syndrome Ganglioside Neuraminidase Deficiency Ml 4 Mucolipidosis 4 Type Iv Mucolipidosis Gangliosidoses
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1
Cerebral Arterial Disease	Cerebral Arterial Diseases

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15698	CRT0066101	Inhibitor	99.88%	Phase 1

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13687	IKK 16	Inhibitor	99.88%	Unkown
HY-15698A	CRT0066101 dihydrochloride	Inhibitor	99.97%	Unkown
HY-13941	1-Naphthyl PP1	Inhibitor	99.36%	Unkown
HY-13687A	IKK 16 hydrochloride	Inhibitor	99.95%	Unkown
HY-12239	CID755673	Inhibitor	99.13%	Unkown
HY-118052	BPKDi	Inhibitor	99.74%	Unkown
HY-13454	CID 2011756	Inhibitor	96.98%	Unkown
HY-15528	kb NB 142-70	Inhibitor	98.02%	Unkown
HY-151374	3-IN-PP1	Inhibitor	99.37%	Unkown
HY-15698B	CRT0066101 trihydrochloride	Inhibitor	/	Unkown
HY-151372	Protein kinase D inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PKD2	RGD	RGD:1559992
Macaca mulatta	PKD2	VGNC	VGNC:100262
Canis familiaris	PKD2	VGNC	VGNC:44600
Felis catus	PKD2	VGNC	VGNC:68871
Bos taurus	PKD2	VGNC	VGNC:32935
Mus musculus	PKD2	MGD	MGI:1099818
Others	PKD2	NCBI