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  3. CID 2011756

CID 2011756 

Cat. No.: HY-13454 Purity: 95.52%
Handling Instructions

CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.

For research use only. We do not sell to patients.

CID 2011756 Chemical Structure

CID 2011756 Chemical Structure

CAS No. : 638156-11-3

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 84 In-stock
Estimated Time of Arrival: December 31
5 mg USD 76 In-stock
Estimated Time of Arrival: December 31
10 mg USD 114 In-stock
Estimated Time of Arrival: December 31
50 mg USD 492 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

CID 2011756 is an ATP competitive PKD inhibitor, with an IC50 of 3.2 µM for PKD1 in cell free assay, and also shows cellular pan-PKD inhibitory activity against PKD2 and PKD3 (IC50, 0.6 and 0.7 µM, respectively). CID 2011756 also has antitumor activity.

IC50 & Target

IC50: 3.2 µM (PKD1), 0.6 µM (Cellular PKD2), 0.7 µM (Cellular PKD3)[1]

In Vitro

CID 2011756 is an ATP-competitive PKD1 inhibitor, with an IC50 of 3.2 µM. CID 2011756 decreases the phosphorylation of endogenous PKD1 Ser916 in LNCaP cancer cells with an EC50 of 10±0.7 µM. CID 2011756 also has cellular pan-PKD inhibitory effects, with IC50s of 0.6±0.1 µM and 0.7±0.2 µM for PKD2 and PKD3, respectively[1].

Molecular Weight

396.87

Formula

C₂₂H₂₁ClN₂O₃

CAS No.

638156-11-3

SMILES

O=C(C1=CC=C(C2=CC=CC(Cl)=C2)O1)NC3=CC=C(CN4CCOCC4)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (50.39 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5197 mL 12.5986 mL 25.1972 mL
5 mM 0.5039 mL 2.5197 mL 5.0394 mL
10 mM 0.2520 mL 1.2599 mL 2.5197 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2 mg/mL (5.04 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2 mg/mL (5.04 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CID 2011756CID2011756CID-2011756PKDProtein kinase DInhibitorinhibitorinhibit

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Product Name:
CID 2011756
Cat. No.:
HY-13454
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