TRPC1 - transient receptor potential cation channel subfamily C member 1 Gene

Also Known as TRP1; HTRP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7220

About TRPC1

Cytogenetic location: 3q23 Genomic coordinates (GRCh38): 3:142,724,034-142,807,888 (from NCBI)

This gene has 5 transcripts (splice variants), 201 orthologues and 5 paralogues. Ubiquitous expression in ovary (RPKM 4.8), endometrium (RPKM 3.9) and 22 other tissues.

Summary

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and Other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

TRPC1 Products (17)

mRNA	Protein	Name
NM_001251845.2	NP_001238774.1	short transient receptor potential channel 1 isoform 1
NM_001413361.1	NP_001400290.1	short transient receptor potential channel 1 isoform 3
NM_001413362.1	NP_001400291.1	short transient receptor potential channel 1 isoform 4
NM_001413363.1	NP_001400292.1	short transient receptor potential channel 1 isoform 5
NM_001413375.1	NP_001400304.1	short transient receptor potential channel 1 isoform 7
NM_001413376.1	NP_001400305.1	short transient receptor potential channel 1 isoform 6
NM_001413377.1	NP_001400306.1	short transient receptor potential channel 1 isoform 8
NM_001413378.1	NP_001400307.1	short transient receptor potential channel 1 isoform 9
NM_001413379.1	NP_001400308.1	short transient receptor potential channel 1 isoform 10
NM_001413380.1	NP_001400309.1	short transient receptor potential channel 1 isoform 11
NM_001413381.1	NP_001400310.1	short transient receptor potential channel 1 isoform 12
NM_001413382.1	NP_001400311.1	short transient receptor potential channel 1 isoform 13
NM_001413383.1	NP_001400312.1	short transient receptor potential channel 1 isoform 14
NM_001413384.1	NP_001400313.1	short transient receptor potential channel 1 isoform 15
NM_001413385.1	NP_001400314.1	short transient receptor potential channel 1 isoform 16
NM_001413386.1	NP_001400315.1	short transient receptor potential channel 1 isoform 17
NM_003304.5	NP_003295.1	short transient receptor potential channel 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	18068335	GOA
enables inositol 1,4,5 trisphosphate binding	IDA IDA: Inferred from direct assay	14505576	GOA
enables monoatomic cation channel activity	EXP EXP: Inferred from Experiment	18995841	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10097141	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	18068335	GOA
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	10097141	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in melanin biosynthetic process	IDA IDA: Inferred from direct assay	8126111	GOA
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	19052258	GOA
involved in regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	19052258	GOA
involved in response to calcium ion	IDA IDA: Inferred from direct assay	14505576	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	14505576	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPC1 Protein Structure

Ank_2

TRP_2

Ion_trans

0
200
400
600
793 a.a.

Protein Preferred Names	Protein Names
short transient receptor potential channel 1	capacitative calcium channel protein Trp1

TRPC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TRPC1	P48995	STIM1	Homo sapiens	Q13586	Anti Bait CoIP	21408196
Intra	TRPC1	P48995	STIM1	Homo sapiens	Q13586	Anti Bait CoIP	19897728
Intra	TRPC1	P48995	CAV1	Homo sapiens	Q03135	Anti Bait CoIP	19897728
Intra	TRPC1	P48995	CAV1	Homo sapiens	Q03135	FRET	19897728
Intra	TRPC1	P48995	CAV1	Homo sapiens	Q03135	Y2H	19897728
Cross	TRPC1	P48995	Trpv4	Mus musculus	Q9EPK8	Anti Bait CoIP	25114176
Intra	TRPC1	P48995	PKD2	Homo sapiens	Q13563	Confocal	10097141
Intra	TRPC1	P48995	PKD2	Homo sapiens	Q13563	Anti Bait CoIP	25114176
Intra	TRPC1	P48995	PKD2	Homo sapiens	Q13563	Anti Tag CoIP	10097141

Cross: Cross-species interaction Intra: Intraspecies interaction

TRPC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82069	TrpC1 Antibody (YA1814)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Pyloric Stenosis
Immunodeficiency 10	Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2 Combined Immunodeficiency Due To Stim1 Deficiency IMD10 Stim1 Deficiency Cid Due To Stim1 Deficiency Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2 Immunodeficiency, Type 10
T Cell And Nk Cell Immunodeficiency
Lymph Node Carcinoma	Lymph Node Cancer Lymph Node Neoplasm Neoplasm Of Lymph Node
Darier-White Disease	Keratosis Follicularis Darier Disease Darier'S Disease DAR DD Darier White Disease Darier Disease Acral Hemorrhagic Type Darier Disease Segmental Darier Disease, Acral Hemorrhagic Type Darier Disease, Segmental
Mucolipidosis Iv	Mucolipidosis Type Iv ML4 Sialolipidosis Mucolipidosis Type 4 Ganglioside Sialidase Deficiency Mliv Ml Iv Berman Syndrome Ganglioside Neuraminidase Deficiency Ml 4 Mucolipidosis 4 Type Iv Mucolipidosis Gangliosidoses
Spondyloepiphyseal Dysplasia, Maroteaux Type	Spondyloepiphyseal Dysplasia Maroteaux Type Pseudo-Morquio Syndrome Type 2 Sed, Maroteaux Type Brachyolmia Type 2 Pseudo-Morquio Syndrome, Type 2 Spondyloepiphyseal Dysplasia Of Maroteaux Brachyolmia Maroteaux Type SEDM Sed Maroteaux Type Dysplasia, Spondyloepiphyseal, Maroteaux Type
Brachyolmia	Brachyrachia
Stormorken Syndrome	Thrombocytopathy, Asplenia, And Miosis Stormorken-Sjaastad-Langslet Syndrome STRMK York Platelet Syndrome Yps Thrombocytopathy, Asplenia And Miosis Thrombocytopathy Asplenia Miosis Thrombocytopathy-Asplenia-Miosis Syndrome Miosis Disorder
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques	Olmsted Syndrome Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques Palmoplantar And Periorificial Keratoderma Olms
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Autosomal Dominant Polycystic Kidney Disease	Polycystic Kidney Disease, Adult Type Adpkd Polycystic Kidney Diseases Polycystic Kidney, Autosomal Dominant Congenital Biliary Ectasias Polycystic Kidney And Hepatic Disease 1 Polycystic Kidney Disease, Autosomal Dominant Kidney, Polycystic, Disease, Autosomal Dominant Adult Polycystic Kidney Disease Polycystic Kidney, Adult Type Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease	Polycystic Kidney Disease 1 PKD1 Adpkd Polycystic Kidney Disease, Adult, Type I Apkd1 Potter Type Iii Polycystic Kidney Disease Polycystic Kidney Disease, Adult Potter Type Iii Polycystic Kidney Disease, Formerly Polycystic Kidney Disease, Type 1 Adpkd1 Adult Polycystic Kidney Disease Type 1 Autosomal Dominant Polycystic Kidney Disease 1 Pkd-1 Polycystic Kidney Disease Adult Polycystic Kidney Disease Type I Polycystic Kidneys Polycystic Kidney Disease, Adult Type I Polycystic Kidney Type 1 Autosomal Dominant Disease Kidney Disease, Polycystic, Type 1 Polycystic Kidney, Autosomal Dominant Polycystic Kidney, Type 1 Autosomal Dominant Disease Polycystic Kidney Diseases
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-138868	17-Phenyl trinor prostaglandin E2 ethyl amide	Agonist	/	Unkown
HY-184164	JD03-02	Antagonist	/	Unkown
HY-RS15104	TRPC1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17997	Trpc1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24469	Trpc1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TRPC1	RGD	RGD:619783
Bos taurus	TRPC1	VGNC	VGNC:36381
Canis familiaris	TRPC1	VGNC	VGNC:47866
Mus musculus	TRPC1	MGD	MGI:109528
Macaca mulatta	TRPC1	VGNC	VGNC:78651
Felis catus	TRPC1	VGNC	VGNC:66581
Others	TRPC1	NCBI