2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. TrpC1 Antibody (YA1814)

TrpC1 Antibody (YA1814) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TrpC1.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

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  • Descripciòn

Descripciòn

TrpC1 Antibody (YA1814) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to TrpC1.
Host

Rabbit
Clonality

Recombinant,Monoclonal
Peso molecular
Predicted band size: 91 kDa;
Observed band size: 120 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthesized peptide derived from human TRPC1 aa411-492.
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Pureza Affinity Chromatography
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in rabbit IgG in 10mM PBS, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide and 50% glycerol.
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Envío

Shipping with blue ice.
Background
Function：Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11139478, PubMed:15016832, PubMed:39478185). Forms a heteromeric ion channel with TRPC4 or TRPC5 that has reduced calcium permeability compared to the homomeric TRPC4 or TRPC5 channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185); Forms a receptor-activated non-selective calcium permeant cation channel. Also activated by intracellular calcium store depletion
Subcellular Localization：Cell membrane; Multi-pass membrane protein
Expression：
Tissue_specificity:Seems to be ubiquitous
Isoforms & Post-Translational Modification：P48995 has 2 isomers: P48995-1: 91212 Da (predicted); P48995-2: 87617 Da (predicted).
Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells
Subunit：Heterotetramer with TRPC4 and/or TRPC5 (PubMed:12032305, PubMed:39478185). Forms a heteromeric ion channel with TRPC4, with a 1:3 TRPC1:TRPC4 stoichiometry (PubMed:39478185). Unlike other TRP channel proteins, does not form a homomeric channel (PubMed:12032305, PubMed:39478185). Interacts with TRPC4AP (By similarity). Interacts with ITPR3 (PubMed:10766822). Interacts with MX1 and RNF24 (PubMed:15757897, PubMed:17850865). Interacts with FKBP4 (PubMed:19945390). Interacts with PLSCR1 (By similarity). Interacts with PKD2L2 (PubMed:16883570). Forms a heterotetramer with PKD2 with a 2:2 stoichiometry; has distinct channel properties separate from PKD2 or TRPC1 homomers alone (PubMed:19193631, PubMed:19850920)
Database

Entrez Gene: 7220 Human ; 22063 Mouse ; 89821 Rat

SwissProt: P48995 Human ; Q61056 Mouse ; Q9QX01 Rat

OMIM: 602343 Human

Research Field

Signal Transduction
Synonyms
HTRP1; Mtrp1; TRP1; TRPC1; Trrp1
Documentación
User Guide for Antibodies (1077 KB)

TrpC1 Antibody (YA1814) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Nombre del producto:
TrpC1 Antibody (YA1814)
Cat. No.:
HY-P82069
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MCE Japan Authorized Agent:

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