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Trpv4 - transient receptor potential cation channel, subfamily V, member 4 Gene

Also Known as Trp12; VRL-2; VROAC; OTRPC4; VR-OAC; 0610033B08Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 63873

Summary

Enables several functions, including SH2 domain binding activity; Calcium Channel activity; and osmosensor activity. Involved in several processes, including cellular hypotonic salinity response; positive regulation of MAPK cascade; and positive regulation of cytokine production. Acts upstream of or within several processes, including hyperosmotic salinity response; osmosensory signaling pathway; and vasopressin secretion. Located in adherens junction; cilium; and plasma membrane. Is expressed in several structures, including autopod; brain; respiratory system; sensory organ; and skeleton. Used to study autosomal dominant nonsyndromic deafness 25. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Apr 2022]

Trpv4 Products (1)

mRNA	Protein	Name
NM_022017.3	NP_071300.2	transient receptor potential cation channel subfamily V member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables SH2 domain binding	IPI IPI: Inferred from physical interaction	12538589	MGI
enables calcium channel activity	IDA IDA: Inferred from direct assay	11025659	MGI
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	18174177	MGI
enables osmosensor activity	IDA IDA: Inferred from direct assay	11025659	MGI
enables osmosensor activity	IMP IMP: Inferred from mutant phenotype	12777254	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	14517216	MGI
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12538589	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion import	IDA IDA: Inferred from direct assay	12538589	MGI
involved in cell-cell junction assembly	IMP IMP: Inferred from mutant phenotype	20413591	MGI
involved in cellular hypotonic response	IDA IDA: Inferred from direct assay	12538589	MGI
involved in cellular hypotonic salinity response	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	18174177	MGI
involved in cellular response to osmotic stress	IMP IMP: Inferred from mutant phenotype	18174177	MGI
involved in diet induced thermogenesis	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in energy homeostasis	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	23021218	MGI
acts upstream of or within hyperosmotic salinity response	IMP IMP: Inferred from mutant phenotype	12777254	MGI
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	18174177	MGI
involved in negative regulation of brown fat cell differentiation	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23021218	MGI
acts upstream of or within osmosensory signaling pathway	IDA IDA: Inferred from direct assay	11025659	MGI
involved in osmosensory signaling pathway	IDA IDA: Inferred from direct assay	12538589	MGI
acts upstream of or within osmosensory signaling pathway	IMP IMP: Inferred from mutant phenotype	12777254	MGI
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of chemokine (C-C motif) ligand 5 production	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of macrophage chemotaxis	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of macrophage inflammatory protein 1 alpha production	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of monocyte chemotactic protein-1 production	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	23136043	MGI
involved in regulation of aerobic respiration	IMP IMP: Inferred from mutant phenotype	23021218	MGI
NOT involved in regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	23021218	MGI
acts upstream of or within regulation of response to osmotic stress	IMP IMP: Inferred from mutant phenotype	12777254	MGI
NOT involved in response to fatty acid	IMP IMP: Inferred from mutant phenotype	23021218	MGI
involved in response to insulin	IMP IMP: Inferred from mutant phenotype	23021218	MGI
NOT involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	23021218	MGI
acts upstream of or within response to osmotic stress	IDA IDA: Inferred from direct assay	11025659	MGI
acts upstream of or within response to osmotic stress	IPI IPI: Inferred from physical interaction	14517216	MGI
acts upstream of or within vasopressin secretion	IMP IMP: Inferred from mutant phenotype	12777254	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in adherens junction	IDA IDA: Inferred from direct assay	20413591	MGI
located in cilium	IDA IDA: Inferred from direct assay	15858826	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	11094154	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12538589	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transient receptor potential cation channel subfamily V member 4	osm-9-like TRP channel 4 osmosensitive transient receptor potential channel 4 transient receptor potential protein 12 trpv4 channel vanilloid receptor-like channel 2 vanilloid receptor-like protein 2 vanilloid receptor-related osmotically-activated

Trpv4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Trpv4	Q9EPK8	UBC	Homo sapiens	P0CG48	Pull Down	17110928
Intra	Trpv4	Q9EPK8	Aqp4	Mus musculus	P55088	Anti Bait CoIP	21262839
Cross	Trpv4	Q9EPK8	PKD2	Homo sapiens	Q13563	Anti Bait CoIP	25114176
Cross	Trpv4	Q9EPK8	TRPC1	Homo sapiens	P48995	Anti Bait CoIP	25114176

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1177	Crotamiton	Inhibitor	98.07%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19765	GSK2798745	Inhibitor	99.80%	Phase 2

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19608	GSK1016790A	Agonist	99.93%	Unkown
HY-100208	HC-067047	Antagonist	99.97%	Unkown
HY-100720	GSK2193874	Antagonist	99.91%	Unkown
HY-120691A	GSK205	Antagonist	99.47%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-19975	RN-1734	Antagonist	99.75%	Unkown
HY-19976	RN-1747	Modulator	99.27%	Unkown
HY-114400	TRPV4 agonist-1 free base	Agonist	99.69%	Unkown
HY-116291	4α-Phorbol 12,13-didecanoate	Agonist	99.30%	Unkown
HY-130573A	DMAPP triammonium	Activator	95.0%	Unkown
HY-160603	PF-05214030	Antagonist	99.81%	Unkown
HY-120962	N-Arachidonoyl Taurine	Activator	99.3%	Unkown
HY-176464	GSK2220691	Inhibitor	99.96%	Unkown
HY-160900	RN-1665	Antagonist	99.93%	Unkown
HY-162765	TRPV4-IN-5	Inhibitor	98.77%	Unkown
HY-120514	JNc-440		98.04%	Unkown
HY-112202	GSK3395879	Antagonist	/	Unkown
HY-142620	TRPV4 antagonist 3	Antagonist	/	Unkown
HY-122692	TRPV4/TRPA1-IN-1	Inhibitor	/	Unkown
HY-178509	TRPV4-KCa2.3 modulator 1	Activator	/	Unkown
HY-149823	TRPV4 antagonist 4	Antagonist	/	Unkown
HY-110270A	RN-9893 hydrochloride	Antagonist	/	Unkown
HY-182455	GSK3527497	Inhibitor	/	Unkown
HY-N2940	Bisandrographolide A	Activator	/	Unkown
HY-W721480	HC-067047 hydrochloride	Antagonist	/	Unkown
HY-181463	20-Hydroxy-N-arachidonoyl taurine	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpv4	NCBI	NCBI:59341