RN-9893 hydrochloride
Based on 1 publication(s) in Google Scholar
RN-9893 Hydrochloride is an orally active antagonist of transient receptor potential vanilloid 4 (TRPV4), with IC50 values of 0.42 and 0.66 μM, for humans and rats, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2109450-40-8
- Formula: C21H24ClF3N4O5S
- Molecular Weight:536.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Description
IC50 & Target
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TRPV4 |
In Vitro
RN-9893 Hydrochloride reveals selectivity towards TRPV1 (IC50: 10 μM), TRPV3 (IC50: >30 μM) and TRPM8 (IC50: 30 μM) [1].
RN-9893 Hydrochloride inhibits rTRPV4 with an IC50 of 0.57 μM when 4α-PDD acts as an agonist. RN-9893 inhibits rTRPV4 with an IC50 of 2.1 μM when hypotonicity is used as agonist[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 2109450-40-8
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Molecular Weight 536.95
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Formula C21H24ClF3N4O5S
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SMILES
O=S(C(C=C1)=CC=C1NC(C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2)=O)(N3CCN(C(C)C)CC3)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Smart Med
Magnetic Reprogramming of Macrophages Stimulates Phagocytosis of Breast Cancer Cells via a TRPC1-STING Inflammatory Axis. [Abstract]2026 Jun 4;5(3):e70038. PMID: 42549352
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RN-9893 hydrochloride Related Classifications
HY-110270A Related Classifications
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