RN-9893 hydrochloride
RN-9893 Hydrochloride is an orally active antagonist of transient receptor potential vanilloid 4 (TRPV4), with IC50 values of 0.42 and 0.66 μM, for humans and rats, respectively.
For research use only. We do not sell to patients.
- CAS No.: 2109450-40-8
- Formula: C21H24ClF3N4O5S
- Molecular Weight:536.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TRPV4 |
RN-9893 Hydrochloride reveals selectivity towards TRPV1 (IC50: 10 μM), TRPV3 (IC50: >30 μM) and TRPM8 (IC50: 30 μM) [1].
RN-9893 Hydrochloride inhibits rTRPV4 with an IC50 of 0.57 μM when 4α-PDD acts as an agonist. RN-9893 inhibits rTRPV4 with an IC50 of 2.1 μM when hypotonicity is used as agonist[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2109450-40-8
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Molecular Weight 536.95
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Formula C21H24ClF3N4O5S
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SMILES
O=S(C(C=C1)=CC=C1NC(C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2)=O)(N3CCN(C(C)C)CC3)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
RN-9893 hydrochloride Related Classifications
HY-110270A Related Classifications
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