2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. RN-9893

RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively.

For research use only. We do not sell to patients.

RN-9893 Chemical Structure

RN-9893 Chemical Structure

CAS No. : 1803003-68-0

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5 mg USD 110 In-stock
10 mg USD 180 In-stock
25 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

RN-9893 is a potent and selective TRPV4 receptor antagonist with IC50 values of 320, 420 and 660 nM for mouse, human and rat channels, respectively[1].

Molecular Weight

500.49

Formula

C21H23F3N4O5S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=S(C(C=C1)=CC=C1NC(C2=C([N+]([O-])=O)C=C(C(F)(F)F)C=C2)=O)(N3CCN(C(C)C)CC3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (499.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9980 mL 9.9902 mL 19.9804 mL
5 mM 0.3996 mL 1.9980 mL 3.9961 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9980 mL 9.9902 mL 19.9804 mL 49.9510 mL
5 mM 0.3996 mL 1.9980 mL 3.9961 mL 9.9902 mL
10 mM 0.1998 mL 0.9990 mL 1.9980 mL 4.9951 mL
15 mM 0.1332 mL 0.6660 mL 1.3320 mL 3.3301 mL
20 mM 0.0999 mL 0.4995 mL 0.9990 mL 2.4976 mL
25 mM 0.0799 mL 0.3996 mL 0.7992 mL 1.9980 mL
30 mM 0.0666 mL 0.3330 mL 0.6660 mL 1.6650 mL
40 mM 0.0500 mL 0.2498 mL 0.4995 mL 1.2488 mL
50 mM 0.0400 mL 0.1998 mL 0.3996 mL 0.9990 mL
60 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8325 mL
80 mM 0.0250 mL 0.1249 mL 0.2498 mL 0.6244 mL
100 mM 0.0200 mL 0.0999 mL 0.1998 mL 0.4995 mL
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RN-9893 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RN-98931803003-68-0RN9893RN 9893TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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