1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. GSK2798745

GSK2798745 

Cat. No.: HY-19765
Handling Instructions

GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure.

For research use only. We do not sell to patients.

GSK2798745 Chemical Structure

GSK2798745 Chemical Structure

CAS No. : 1419609-94-1

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Description

GSK2798745 is a first-in-class, highly potent, selective, orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker with IC50s of 1.8 and 1.6 nM for hTRPV4 and rTRPV4, respectively. GSK2798745 is used in research for the treatment of pulmonary edema associated with congestive heart failure[1][2].

IC50 & Target

IC50: 1.8 nM (hTRPV4) and 1.6 nM (rTRPV4)[2]

Molecular Weight

460.53

Formula

C₂₅H₂₈N₆O₃

CAS No.

1419609-94-1

SMILES

N#CC1=CC=C2N=CN(C[[email protected]](CCC3)(C)C[[email protected]@]43CN(C5=NC=C(C(C)(O)C)N=C5)C(O4)=O)C2=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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GSK2798745
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HY-19765
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