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Cat. No.: HY-142620

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TRPV4 antagonist 3

TRPV4 antagonist 3 is a TRPV4 antagonist (pIC₅₀ = 8.4).

For research use only. We do not sell to patients.

CAS No.: 2681273-35-6
Formula: C₂₀H₁₈F₄N₄O₃S
Molecular Weight:470.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

TRPV4 antagonist 3 Chemical Structure

CAS No.: 2681273-35-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

TRPV4 antagonist 3 is a TRPV4 antagonist (pIC₅₀ = 8.4).

IC₅₀ & Target

TRPV4

All TRP Channel Isoforms :

Chemical Information

CAS No. 2681273-35-6
Molecular Weight 470.44
Formula C₂₀H₁₈F₄N₄O₃S
SMILES

O=S(C1=CC=C(C#N)C=C1C(F)(F)F)(NCC[C@](C)(N)COC2=CC=C(C#N)C(F)=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Patterson JR, et al. Design and Optimization of an Acyclic Amine Series of TRPV4 Antagonists by Electronic Modulation of Hydrogen Bond Interactions. J Med Chem. 2020 Dec 10;63(23):14867-14884. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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TRPV4 antagonist 3

All TRP Channel Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TRPV4 antagonist 3 Related Classifications

HY-142620 Related Classifications