HC-067047 hydrochloride
Based on 42 publication(s) in Google Scholar
HC-067047 hydrochloride is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1481646-76-7
- Formula: C26H29ClF3N3O2
- Molecular Weight:507.98
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) HC-067047 hydrochloride
More- Signal Transduct Target Ther. 2025 Nov 28;10(1):388. [Abstract]
- Nat Immunol. 2026 May;27(5):949-960. [Abstract]
- Nat Commun. 2026 Feb 26;17(1):3254. [Abstract]
- Redox Biol. 2026 Jun 11:95:104255. [Abstract]
- Cell Death Dis. 2023 Jun 28;14(6):379. [Abstract]
- Acta Pharmacol Sin. 2023 Apr;44(4):811-821. [Abstract]
- Antioxidants (Basel). 2022 Nov 23;11(12):2315. [Abstract]
- Cell Mol Neurobiol. 2023 Apr;43(3):1283-1300. [Abstract]
- Environ Pollut. 2020 Jan:256:113375. [Abstract]
- Sci Signal. 2025 Dec 23;18(918):eadt1539. [Abstract]
- Acta Neuropathol Commun. 2025 Apr 10;13(1):73. [Abstract]
- Life Sci. 2025 Feb 15:363:123415. [Abstract]
- Transl Res. 2024 Apr:266:16-31. [Abstract]
- Eur J Pharmacol. 2025 Sep 5:1002:177807. [Abstract]
- Eur J Pharmacol. 2025 Sep 15:1003:177900. [Abstract]
- Eur J Pharmacol. 2023 Dec 5:960:176140. [Abstract]
- Acta Physiol. 2023 Apr;237(4):e13926. [Abstract]
- Int Immunopharmacol. 2025 Sep 10:165:115453. [Abstract]
- Mol Neurobiol. 2025 Mar;62(3):3615-3629. [Abstract]
- Front Pharmacol. 2021 Jul 14:12:684538. [Abstract]
- ACS Omega. 2025 Aug 21;10(34):39192-39202. [Abstract]
- Brain Pathol. 2025 Nov;35(6):e70022. [Abstract]
- Sci Rep. 2025 Nov 24;15(1):41644. [Abstract]
- Cell Signal. 2024 Feb:114:110973. [Abstract]
- Aquaculture. 2021, 736537.
- J Biol Chem. 2022 May;298(5):101847. [Abstract]
- J Cell Physiol. 2023 Nov;238(11):2692-2709. [Abstract]
- Mol Pain. 2024 Jan-Dec:20:17448069241272149. [Abstract]
- Am J Physiol Lung Cell Mol Physiol. 2020 Apr 1;318(4):L723-L741. [Abstract]
- J Cancer. 2025 Jan 13;16(4):1324-1334. [Abstract]
- Exp Eye Res. 2023 Mar:228:109405. [Abstract]
- Neurogastroenterol Motil. 2025 Dec;37(12):e70104. [Abstract]
- Biomed Res Int. 2022 Jan 4:2022:2777882. [Abstract]
- Physiol Behav. 2026 Feb:304:115159. [Abstract]
- Exp Ther Med. 2022 Jun 1;24(1):478. [Abstract]
- Traditional Medicine Research. 2026;11(2):11.
- Biol Bull. 2022 Feb;242(1):48-61. [Abstract]
- SSRN. 2025 Dec 12.
- Heliyon. 2023 Jun 23;9(7):e17583. [Abstract]
- Research Square Preprint. 2021 Dec.
- Biomed Pharmacother. 2020 Feb;122:109697. [Abstract]
- Biomed Pharmacother. 2018 Dec:108:540-546. [Abstract]
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Biological Activity
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TRPV4 |
HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases mRNA expression in high glucose cultured HEI-OC1 cells[2].
HC-067047 (1 μM; 24 hours; HEI-OC1 cells) treatment significantly decreases the expression of TRPV4 protein[2].
HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment inhibits cell proliferation[2].
HC-067047 (1 μM; 48 hours; HEI-OC1 cells) treatment promotes cell apoptosis[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1481646-76-7
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Molecular Weight 507.98
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Formula C26H29ClF3N3O2
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SMILES
CC1=C(C(NC2=CC(C(F)(F)F)=CC=C2)=O)C=C(C3=CC=CC=C3)N1CCCN4CCOCC4.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (42)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Pulsed electromagnetic fields inhibit atherosclerosis by regulating pyroptosis through membrane tension-mediated mechanosensitive channels. [Abstract]2025 Nov 28;10(1):388. PMID: 41309549
HC-067047 hydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388. [Abstract]
HC067047 (100 nM, transient administration) blocked both GSK1016790A (80 nM,transient administration) -evoked inward and outward transmembrane currents in HUVEC cells.
HC-067047 hydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388. [Abstract]
HC067047 (1 µM, 2 h) decreased cell height and increased cell body area in HUVEC cells.
HC-067047 hydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388. [Abstract]
HC067047 (1 µM, 2 h) compromised mitochondrial function, including a reduction in membrane potential, in HUVEC cells.
HC-067047 hydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388. [Abstract]
HC067047 (1 µM, 2 h) increased basal respiration, maximal respiration, ATP production, and spare capacity in HUVEC cells.
HC-067047 hydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388. [Abstract]
HC067047 (1 µM, 2 h) decreased TRPV4, NLRP3, ASC, and p20 caspase-1 protein expression in HUVECs.
HC-067047 hydrochloride purchased from MedChemExpress. Usage Cited in: Signal Transduct Target Ther. 2025 Nov 28;10(1):388. [Abstract]
HC067047 (10 mg/kg, tail vein injection, every 48 h for 3 weeks) decreased lesion size in the aorta of ApoE-/- mice.
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Nat Immunol
Lipid asymmetry disruption by XKR8 orchestrates neutrophil extracellular trap formation and inhibits fungal infection. [Abstract]2026 May;27(5):949-960. PMID: 41781710 -
Nat Commun
2026 Feb 26;17(1):3254. PMID: 41748583 -
Redox Biol
TRPV4 drives macrophage pyroptosis via mitochondrial dysfunction and mtROS-dependent NLRP3 inflammasome activation in acute lung injury. [Abstract]2026 Jun 11:95:104255. PMID: 42314332 -
Cell Death Dis
Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma. [Abstract]2023 Jun 28;14(6):379. PMID: 37369706 -
Acta Pharmacol Sin
TRPV4 channel is involved in HSV-2 infection in human vaginal epithelial cells through triggering Ca2+ oscillation. [Abstract]2023 Apr;44(4):811-821. PMID: 36151392 -
Antioxidants (Basel)
Blocking TRPV4 Ameliorates Osteoarthritis by Inhibiting M1 Macrophage Polarization via the ROS/NLRP3 Signaling Pathway. [Abstract]2022 Nov 23;11(12):2315. PMID: 36552524 -
Cell Mol Neurobiol
Blockage of TRPV4 Downregulates the Nuclear Factor-Kappa B Signaling Pathway to Inhibit Inflammatory Responses and Neuronal Death in Mice with Pilocarpine-Induced Status Epilepticus. [Abstract]2023 Apr;43(3):1283-1300. PMID: 35840809 -
Environ Pollut
Exposure to both formaldehyde and high relative humidity exacerbates allergic asthma by activating the TRPV4-p38 MAPK pathway in Balb/c mice. [Abstract]2020 Jan:256:113375. PMID: 31662264 -
Sci Signal
The mechanosensitive channel TRPV4 inhibits pulmonary inflammation by limiting NF-κB signaling in alveolar macrophages. [Abstract]2025 Dec 23;18(918):eadt1539. PMID: 41433421 -
Acta Neuropathol Commun
Transient receptor potential vanilloid 4 blockage attenuates pyroptosis in hippocampus of mice following pilocarpine‑induced status epilepticus. [Abstract]2025 Apr 10;13(1):73. PMID: 40205503 -
Life Sci
Identification and regulation of a novel leptin receptor-linked enhancer during zebrafish ventricle regeneration. [Abstract]2025 Feb 15:363:123415. PMID: 39864617 -
Transl Res
TRPV4 in adipose tissue ameliorates diet-induced obesity by promoting white adipocyte browning. [Abstract]2024 Apr:266:16-31. PMID: 37926276 -
Eur J Pharmacol
Morin ameliorates coronary artery relaxation by activating TRPV4-eNOS-NO signalling in high-salt diet-fed rats. [Abstract]2025 Sep 5:1002:177807. PMID: 40472987 -
Eur J Pharmacol
Novel mechanisms of metformin-induced vasorelaxation of mesenteric arterioles via endothelium-dependent hyperpolarization to treat murine colitis. [Abstract]2025 Sep 15:1003:177900. PMID: 40617384 -
Eur J Pharmacol
Pregabalin inhibits purinergic P2Y2 receptor and TRPV4 to suppress astrocyte activation and to relieve neuropathic pain. [Abstract]2023 Dec 5:960:176140. PMID: 37925132 -
Acta Physiol
2023 Apr;237(4):e13926. PMID: 36606511 -
Int Immunopharmacol
Osthole alleviates neuropathic pain by suppressing astrocytes activation and associated inflammatory responses via the PKCδ/TRPV4 signaling pathway. [Abstract]2025 Sep 10:165:115453. PMID: 40934539 -
Mol Neurobiol
TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus. [Abstract]2025 Mar;62(3):3615-3629. PMID: 39312069 -
Front Pharmacol
Role of Serosal TRPV4-Constituted SOCE Mechanism in Secretagogues-Stimulated Intestinal Epithelial Anion Secretion. [Abstract]2021 Jul 14:12:684538. PMID: 34335254 -
ACS Omega
2025 Aug 21;10(34):39192-39202. PMID: 40918390 -
Brain Pathol
Targeting TRPV4 to restore glymphatic system function and alleviate cerebral edema in ischemic stroke. [Abstract]2025 Nov;35(6):e70022. PMID: 40481713 -
Sci Rep
The TRPV4-YAP axis mediates cytoskeletal and extracellular matrix remodeling in trabecular meshwork cells as a novel glaucoma mechanism. [Abstract]2025 Nov 24;15(1):41644. PMID: 41286165 -
Cell Signal
TRPV4 blockade alleviates endoplasmic reticulum stress mediated apoptosis in hypoxia-induced cardiomyocyte injury. [Abstract]2024 Feb:114:110973. PMID: 37981067 -
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J Biol Chem
Capsaicin inhibits intestinal Cl- secretion and promotes Na+ absorption by blocking TRPV4 channels in healthy and colitic mice. [Abstract]2022 May;298(5):101847. PMID: 35314195 -
J Cell Physiol
Simulated microgravity-induced oxidative stress and loss of osteogenic potential of osteoblasts can be prevented by protection of primary cilia. [Abstract]2023 Nov;238(11):2692-2709. PMID: 37796139 -
Mol Pain
Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome. [Abstract]2024 Jan-Dec:20:17448069241272149. PMID: 39079948 -
Am J Physiol Lung Cell Mol Physiol
Adipose-derived exosomes protect the pulmonary endothelial barrier in ventilator-induced lung injury by inhibiting the TRPV4/Ca2+ signaling pathway. [Abstract]2020 Apr 1;318(4):L723-L741. PMID: 32073873 -
J Cancer
Matrix stiffness regulates NPC invasiveness by modulating a mechanoresponsive TRPV4-Nox4-IL-8 signaling axis. [Abstract]2025 Jan 13;16(4):1324-1334. PMID: 39895789 -
Exp Eye Res
2023 Mar:228:109405. PMID: 36773739 -
Neurogastroenterol Motil
Shugan Decoction Ameliorated WAS-Induced Abnormal Colonic Motility in Rats by Inhibiting Colonic TRPV4-PGE2 Signaling. [Abstract]2025 Dec;37(12):e70104. PMID: 40545667 -
Biomed Res Int
Role of TRPV4 in the Diagnosis and Treatment of Helicobacter pylori Infection in Children with Duodenal Ulcers. [Abstract]2022 Jan 4:2022:2777882. PMID: 35028313 -
Physiol Behav
Rising TRPV4 expression in the central nucleus of amygdala is involved in tooth movement pain. [Abstract]2026 Feb:304:115159. PMID: 41203189 -
Exp Ther Med
Ketamine administration ameliorates anesthesia and surgery-induced cognitive dysfunction via activation of TRPV4 channel opening. [Abstract]2022 Jun 1;24(1):478. PMID: 35761804 -
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Biol Bull
Functional Characterization of TRPV-Like Ion Channels Involved in Nematocyst Discharge from the Sea Anemone Diadumene lineata. [Abstract]2022 Feb;242(1):48-61. PMID: 35245164 -
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Heliyon
The role of TRPV4 in the regulation of retinal ganglion cells apoptosis in rat and mouse. [Abstract]2023 Jun 23;9(7):e17583. PMID: 37456002 -
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Biomed Pharmacother
The effect of transient receptor potential vanilloid 4 on the intestinal epithelial barrier and human colonic cells was affected by tyrosine-phosphorylated claudin-7. [Abstract]2020 Feb;122:109697. PMID: 31918271 -
Biomed Pharmacother
The effect of serine phosphorylated claudin-7 on the epithelial barrier and the modulation by transient receptor potential vanilloid 4 in human colonic cells. [Abstract]2018 Dec:108:540-546. PMID: 30243087
Purity & Documentation
References
[1]. Everaerts W et al. Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis.Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19084-9. [Content Brief]
[2]. Xing Y, et al. Decreased Expression of TRPV4 Channels in HEI-OC1 Cells Induced by High Glucose Is Associated with Hearing Impairment. Yonsei Med J. 2018 Nov;59(9):1131-1137. [Content Brief]
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HC-067047 hydrochloride Related Classifications
HY-W721480 Related Classifications
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