1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. TRP Channel
  3. TRPV4 agonist-1

TRPV4 agonist-1 

Cat. No.: HY-114400
Handling Instructions

TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay.

For research use only. We do not sell to patients.

TRPV4 agonist-1 Chemical Structure

TRPV4 agonist-1 Chemical Structure

CAS No. : 2314467-60-0

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Description

TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].

IC50 & Target

EC50: 60 nM (hTRPV4 hTRPV4 Ca2+)[1]

In Vitro

TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels[1].

Molecular Weight

484.93

Formula

C₂₅H₂₃ClF₂N₄O₂

CAS No.

2314467-60-0

SMILES

O=C1N(C2=CC=C(OC3=CC=C(F)C=C3)C=C2)C(N4CCN(C)CC4)=NC5=C(F)C=CC=C51.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TRPV4 agonist-1TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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