TRPV4 agonist-1
TRPV4 agonist-1 is a transient receptor potential vanilloid 4 (TRPV4) agonist with an EC50 of 60 nM in the hTRPV4 Ca2+ assay[1].
For research use only. We do not sell to patients.
- CAS No.: 2314467-60-0
- Formula: C25H23ClF2N4O2
- Molecular Weight:484.93
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
EC50: 60 nM (hTRPV4 hTRPV4 Ca2+)[1]
TRPV4 agonist-1 (Compound 36) exhibits significantly increased potency (ECmax: 20 nM in the SOX9 reporter assay). TRPV4 agonist-1 is inactive against TRPV1 channels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2314467-60-0
-
Molecular Weight 484.93
-
Formula C25H23ClF2N4O2
-
SMILES
O=C1N(C2=CC=C(OC3=CC=C(F)C=C3)C=C2)C(N4CCN(C)CC4)=NC5=C(F)C=CC=C51.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Atobe M, et al. Discovery of Novel Transient Receptor Potential Vanilloid 4 (TRPV4) Agonists as Regulators of Chondrogenic Differentiation: Identification of Quinazolin-4(3 H)-ones and in Vivo Studies on a Surgically Induced Rat Model of Osteoarthritis. J Med Chem. 2019 Feb 14;62(3):1468-1483. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz