Bisandrographolide A
Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound.
For research use only. We do not sell to patients.
- CAS No.: 160498-00-0
- Formula: C40H56O8
- Molecular Weight:664.87
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
TRPV4 790-950 nM (IC50) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 160498-00-0
-
Molecular Weight 664.87
-
Formula C40H56O8
-
SMILES
O=C1C(C(C2C=C(/C=C/[C@H]3[C@@](CC[C@@H](O)[C@@]4(C)CO)(C)[C@]4([H])CCC3=C)C(O2)=O)C[C@H]5[C@@](CC[C@@H](O)[C@@]6(C)CO)(C)[C@]6([H])CCC5=C)=CCO1
-
Synonyms
BAA
-
Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Yue GG, et al. Identification of active components in Andrographis paniculata targeting on CD81 in esophageal cancer in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154183. [Content Brief]
[2]. Vriens J, et al. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem. 2007 Apr 27;282(17):12796-803. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz