160498-00-0
Chemical Structure
Bisandrographolide A
Synonym(s): BAA
- CAS No.: 160498-00-0
- Formula:C40H56O8
- Molecular Weight:664.87
IUPAC Name: 5-(2-((1R,4aS,5R,6R,8aS)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)-1-(2-oxo-2,5-dihydrofuran-3-yl)ethyl)-3-((E)-2-((1R,4aS,5R,6R,8aR)-6-hydroxy-5-(hydroxymethyl)-5,8a-dimethyl-2-methylenedecahydronaphthalen-1-yl)vinyl)furan-2(5H)-one
InChIKey: WQHWOZANSOUSAY-LZBAHHAZSA-N
SMILES: O=C1C(C(C2C=C(/C=C/[C@H]3[C@@](CC[C@@H](O)[C@@]4(C)CO)(C)[C@]4([H])CCC3=C)C(O2)=O)C[C@H]5[C@@](CC[C@@H](O)[C@@]6(C)CO)(C)[C@]6([H])CCC5=C)=CCO1
Biological Activity: Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound[1][2].
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Bisandrographolide A | Bisandrographolide A (BAA) activates TRPV4 channel with an EC50 of 790-950 nM. Bisandrographolide A can bind to CD81 and suppress its function. Bisandrographolide A is an anti-inflammatory, immunostimulant, and antihypertensive compound. | |||||||||||||||||||||
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- [1]. Yue GG, et al. Identification of active components in Andrographis paniculata targeting on CD81 in esophageal cancer in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154183. [Content Brief]
- [2]. Vriens J, et al. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem. 2007 Apr 27;282(17):12796-803. [Content Brief]
Keywords
