1. Membrane Transporter/Ion Channel
  2. TRP Channel

GSK1016790A 

Cat. No.: HY-19608 Purity: 98.07%
Handling Instructions

GSK101 (GSK1016790A) is a novel TRPV4 activator.

For research use only. We do not sell to patients.

GSK1016790A Chemical Structure

GSK1016790A Chemical Structure

CAS No. : 942206-85-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 121 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 144 In-stock
Estimated Time of Arrival: December 31
25 mg USD 300 In-stock
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Estimated Time of Arrival: December 31
100 mg USD 900 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

In vitro: In HeLa cells transiently transfected with TRPV4 (HeLa-TRPV4). GSK101 (10 nM) causes a TRPV4 specific Ca2+ influx in HeLa-TRPV4 cells, but not in control transfected cells, which can be inhibited by ruthenium red and Ca2+-free medium more significantly at the early stage of the activation rather than the late stage, reflecting apparent partial desensitization.[1] In vivo: Concomitant activation of NO and EDHF by TRPV4 channel agonist GSK1016790A (GSK) in the rat pulmonary artery. [2]

Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (50.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5253 mL 7.6265 mL 15.2530 mL
5 mM 0.3051 mL 1.5253 mL 3.0506 mL
10 mM 0.1525 mL 0.7626 mL 1.5253 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

655.61

Formula

C₂₈H₃₂Cl₂N₄O₆S₂

CAS No.

942206-85-1

SMILES

O=C(C1=CC2=CC=CC=C2S1)N[[email protected]](C(N3CCN(C([[email protected]@H](NS(=O)(C4=CC=C(Cl)C=C4Cl)=O)CO)=O)CC3)=O)CC(C)C

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
GSK1016790A
Cat. No.:
HY-19608
Quantity:

GSK1016790A

Cat. No.: HY-19608