2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. TRPV4 antagonist 4

TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC50 value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury.

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TRPV4 antagonist 4 Chemical Structure

TRPV4 antagonist 4 Chemical Structure

CAS No. : 2918803-89-9

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TRPV4 antagonist 4 Related Antibodies

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Description

TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC50 value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury[1].

IC50 & Target[1]

TRPV4

22.65 nM (IC50)

In Vitro

TRPV4 antagonist 4 (compound 2b; 1 µM) inhibits GSK1016790A (HY-19608) (100 nM)-induced TRPV4 whole-cell currents in TRPV4-CHO cells[1].
TRPV4 antagonist 4 suppresses the permeability response to LPS (HY-D1056) in HUVEC[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TRPV4 antagonist 4 Related Antibodies
In Vivo

TRPV4 antagonist 4 (1 mg/kg; i.p.) improves the pneumonedema, the lung pathologic changes in LPS-induced mouse lung injury mode[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice (acute lung injury (ALI))[1]
Dosage: 1 mg/kg
Administration: I,p.; before LPS inhalation
Result: Displayed significant effects to reduce the lung W/D ratio and significantly decreased the concentrations of BALF protein, significantly blocked the permeability response to LPS stimulates, greatly improved the pneumonedema, the lung pathologic changes in LPS-induced mouse lung injury mode.
Molecular Weight

539.50

Formula

C28H32Cl2N6O
CAS No.
SMILES

N#CC1(CCC1)C2=CC=C(N3CCC(CC3)N4C(NC(C)C)=NC5=C(NC(C)=O)C(Cl)=C(Cl)C=C54)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TRPV4 antagonist 4 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRPV4 antagonist 42918803-89-9TRP ChannelTransient receptor potential channelsTRPV4 currentacute lung injurypermeability responseInhibitorinhibitorinhibit

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TRPV4 antagonist 4
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HY-149823
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