TRPV4 antagonist 4
TRPV4 antagonist 4 is a potent TRPV4 antagonist with an IC50 value of 22.65 nM. TRPV4 antagonist 4 inhibits TRPV4 current. TRPV4 antagonist 4 shows protective effects on acute lung injury.
For research use only. We do not sell to patients.
- CAS No.: 2918803-89-9
- Formula: C28H32Cl2N6O
- Molecular Weight:539.50
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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TRPV4 22.65 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HUVEC | CC50 |
>100 μM
Compound: 2b
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Cytotoxicity against human HUVEC cells assessed as reduction in cell viability
Cytotoxicity against human HUVEC cells assessed as reduction in cell viability
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[PMID: 36696767] |
TRPV4 antagonist 4 (compound 2b; 1 µM) inhibits GSK1016790A (HY-19608) (100 nM)-induced TRPV4 whole-cell currents in TRPV4-CHO cells[1].
TRPV4 antagonist 4 suppresses the permeability response to LPS (HY-D1056) in HUVEC[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mice (acute lung injury (ALI))[1]
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Dosage:1 mg/kg
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Administration:I,p.; before LPS inhalation
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Result:Displayed significant effects to reduce the lung W/D ratio and significantly decreased the concentrations of BALF protein, significantly blocked the permeability response to LPS stimulates, greatly improved the pneumonedema, the lung pathologic changes in LPS-induced mouse lung injury mode.
Chemical Information
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CAS No. 2918803-89-9
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Molecular Weight 539.50
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Formula C28H32Cl2N6O
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SMILES
N#CC1(CCC1)C2=CC=C(N3CCC(CC3)N4C(NC(C)C)=NC5=C(NC(C)=O)C(Cl)=C(Cl)C=C54)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TRPV4 antagonist 4 Related Classifications
HY-149823 Related Classifications
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