(R,S,R)-TRPV4 antagonist 5
(R,S,R)-TRPV4 antagonist 5 (example 5B) is a TRPV4 antagonist. (R,S,R)-TRPV4 antagonist 5 inhibits calcium influx by antagonizing TRPV4 channels, thereby blocking cellular responses triggered by mechanical stress, heat, or chemical stimuli.
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- CAS No.: 3026084-13-6
- Formula: C25H27FN6O3
- Molecular Weight:478.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
TRPV4 |
Chemical Information
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CAS No. 3026084-13-6
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Molecular Weight 478.52
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Formula C25H27FN6O3
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SMILES
C[C@@]1(C[C@]2(CC[C@@H]1F)CN(C3=NC=C(C(C)(O)C)N=C3)C(O2)=O)CN4C5=CC(C#N)=CC=C5N=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Ca2+ Staining Technique
Ca2+ staining is an experimental technique that utilizes specific fluorescent probes (such as Fluo-4 AM, Fura-2, etc.) to qualitatively or quantitatively detect dynamic changes in intracellular Ca2+ concentrations; this is achieved by monitoring the changes in fluorescent signals generated when these probes bind to free intracellular calcium ions. The underlying principle relies primarily on the presence of chelating groups within the probe's molecular structure that possess high affinity for calcium ions.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R,S,R)-TRPV4 antagonist 5 Related Classifications
HY-185006A Related Classifications
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